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TranscriptomicsTranscription profiling of human LNCaP cells treated with DHT, RTI-6413-018 or vehicle to identify useful Selective Androgen Receptor Modulators (SARMs)
We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, enable AR to adopt structures distinct from that observed in the presence of canonical agonists. In this report, we describe the use of these compounds to establish a relationship between AR structure ...
ORGANISM(S): Homo sapiens 
2007-12-19 | E-GEOD-4636 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer
In this study, we have utilized microarray analysis to directly compare a subset of structurally distinct, clinically relevant SERMs in the presence and absence of estradiol, using a high replicate number (10) to ensure detection of modestly regulated genes. Tested compounds included 4-hydroxytamoxi...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-35428 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF7 cells were infected with adenovirus overexpressing one of the four proteins (PGC1 WT, PGC1 2x9, PGC1 L2L3 and BGAL) reveals cross-talk between Estrogen Receptor-related Receptor alpha (ERRalpha) and Estrogen Receptor (ERalpha) pathways.
Orphan nuclear receptor estrogen-related receptor alpha (ERRα) has recently been shown to carry negative prognostic significance in breast and ovarian cancers. The specific role of ERRα in tumor growth and progression, however, is yet to be fully understood. The significant homology between estro...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11266 | biostudies-arrayexpress
TranscriptomicsRole of estrogen related receptor alpha (ERRa) in CD4+ T cell gene expression
ERRa is an orphan nuclear receptor with an established role in cell metabolism. Our studies demonstrate that acute or chronic loss of ERRa broadly affects mitochondrial and glycolytic metabolism in CD4+ T cells and results in diminished T cell function and differentation. In this array, we assessed ...
ORGANISM(S): Mus musculus 
2011-10-20 | E-GEOD-33108 | biostudies-arrayexpress
TranscriptomicsThe expression programme of ERR-alphain human mammary epithelial cells
This dataset is part of the manuscript titled "The metabolic regulator ERRalpha, a downstream target of HER2/IGF1, as a therapeutic target in breast cancer" (in review). The expression data obtained in human mammary epithelial cells were used to generate a list of ERRalpha-regulated genes that was l...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-23061 | biostudies-arrayexpress
TranscriptomicsAn angiogenic role for the aryl hydrocarbon receptor in choroidal neovascularization
We report that decreased expression and activity of AhR exacerbates murine neovascular age-related macular degeneration, and increases cell migration and tube formation. The mechanism involves increased expression of pro-angiogenic mediators and altered matrix degradation. The results of our study s...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-56983 | biostudies-arrayexpress
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