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GenomicsThe Kdm5c histone demethylase controls enhancer and promoter function.
Here, we show that the Kdm5c/Smcx member of the Jarid1 family of H3K4 demethylases is recruited to both enhancer and core promoter elements in ES and neuronal progenitor cells (NPC). Knockdown of Kdm5c deregulates transcription via a local increase in H3K4me3. While at core promoters the function of...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-34975 | biostudies-arrayexpress
TranscriptomicsNO001: Kdm5c controls promoter and enhancer activities
The functional organization of eukaryotic genomes correlates with specific patterns of histone methylations. Regulatory regions in genomes like enhancers and promoters differ in their extent of methylation of histone H3 at lysine-4 (H3K4), but it is largely unknown how the different methylation stat...
ORGANISM(S): Mus musculus 
2013-04-05 | E-GEOD-38862 | biostudies-arrayexpress
TranscriptomicsNO001: Kdm5c controls promoter and enhancer activities
RNA from four independent cultures from each sh Kdm5c #1, sh Kdm5c #2 and non-targeting shRNA polyclonal cell lines were hybridized in dye-swap against a common reference of RNA from IB10 ES cells
ORGANISM(S): Mus musculus 
2013-04-05 | E-MTAB-1177 | biostudies-arrayexpress
ProteomicsThe Histone Demethylase KDM5C Functions as a Tumor Suppressor in AML by Repression of B ivalently M arked Immature Genes
To uncover novel epigenetic regulators in AML, we performed an in vivo short hairpin RNA (shRNA) screen in the context of Cebpa mutant AML. This led to the identification of the Histone 3 Lysine 4 (H3K4) demethylase, KDM5C, as a novel tumor suppressor in AML. KDM5C potentially functions as a transcr...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD016568 | Pride
Human Leukemia Kdm5c 
TranscriptomicsKDM5C safeguards the appropriate timing of early neurodevelopment
We generated human induced pluripotent cells from intellectual disability patients carrying the c.2T>C mutation in KDM5C (Called “Mutant”). We generated a paired, isogenic human iPS cell line (called “Corrected”) using CRISPR/Cas9 and PiggyBac gene-editing technologies and conducted neuronal differe...
ORGANISM(S): Homo sapiens 
2023-10-13 | E-MTAB-7551 | biostudies-arrayexpress
TranscriptomicsRole of Kdm5c knock down in Hypoxia in LLC cells
We investigated the role of Kdm5c in LLC cell line under hypoxic condition. Cells were stably transduced with shRNAs against Kdm5c. The expression profiles of them was compared to LLC cells transduced with empty vector control. Cells were cultured in 0.5% O2 for 48 hours.
ORGANISM(S): Mus musculus 
2026-09-16 | E-MTAB-6746 | biostudies-arrayexpress
TranscriptomicsRole of Kdm5c, Cd44 and Csf1 knock down in LLC cells
We investigated the role of Kdm5c, Csf1 and Cd44 in LLC cell line. Cells were stably transduced with shRNAs against these genes. The expression profiles of these samples were compared to LLC cells transduced with empty vector control.
ORGANISM(S): Mus musculus 
2026-09-16 | E-MTAB-6745 | biostudies-arrayexpress
TranscriptomicsRole of KDM5C knock down in human renal cell carcinoma under Sunitinib treatment
Human renal cell carcinoma cell line 786-O was stably transduced with shKDM5C or empty vector. Then KDM5C was rescued in shKDM5C and over expressed in cells with empty vector. The cells were used to produce tumors in nude mice and were treated with Sunitinib (SU-11248, Pfizer, Inc., New Yourk) at do...
ORGANISM(S): Homo sapiens 
2026-09-16 | E-MTAB-6748 | biostudies-arrayexpress
TranscriptomicsscGET-seq profile of NIH-3T3 cells with Kdm5c knockdown
scGET-seq profiling of NIH3T3 cells in which Kdm5c was silenced with antisense shRNA or with a control scramble shRNA.
ORGANISM(S): Mus musculus 
2021-08-17 | E-MTAB-9651 | biostudies-arrayexpress
GenomicsRole of KDM5C knock down on histone marks
Role of KDM5C knock down on histone marks
PRJEB39716 | ENA
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