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MetabolomicsTimecourse on RAW 264.7 cells treated with Kdo2-Lipid A and compactin
Not available
ORGANISM(S): Mus musculus 
ST000005 | MetabolomicsWorkbench
UnknownEvolution of the Kdo2-lipid A biosynthesis in bacteria.
Not available
S-EPMC3087551 | biostudies-literature
ProteomicsMacrophage Proteomic Profiling Reveals Divergent TLR4-Dependent and -Independent Responses to Kdo₂-Lipid A and Lipid IVa
Immortalized mouse macrophages from wild type (WT) were treated with Kdo₂-Lipid A and Lipid IVa under three experimental conditions: (i) extracellular stimulation to assess TLR4-dependent activation with Kdo2 lipid A or lipid-IVa (Extra_Kdo2/Extra_IVa), (ii) direct cytosolic delivery by transfection...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD075293 | Pride
Kdo2-lipid a Lipid iva Tlr4-independent Macrophages Tlr4-dependent Proteomics 
TranscriptomicsIFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses
Gene expression for mouse C57BL/6 bone marrow derived macrophages stimulated with a titration matrix of TLR4 and TLR2 ligand, KDO2-Lipid A and Pam3CSK4, respectively
ORGANISM(S): Mus musculus 
2019-08-06 | GSE117842 | GEO
TranscriptomicsLow and high dose TLR4 stimulation in bone-marrow derived mouse macrophages
The goal of this study was to compare gene expression in mouse bone marrow-derived macrophages stimulated with high or low doses of the TLR4 ligand Kdo2-Lipid A.
ORGANISM(S): Mus musculus 
2016-04-12 | GSE70510 | GEO
TranscriptomicsEffect of hBD3 on transcription in TLR4-stimulated macrophages
This SuperSeries is composed of the following subset Series: GSE25870: Human Beta-Defensin 3 attenuates the pro-inflammatory effects of LPS at 1 hour GSE25871: Human Beta-Defensin 3 attenuates the pro-inflammatory effects of KDO2-Lipid A (KLA) at 6 hour Refer to individual Series
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-25873 | biostudies-arrayexpress
UnknownTopology and patch-clamp analysis of the sodium channel in relationship to the anti-lipid a antibody in campylobacteriosis.
Not available
S-EPMC2631156 | biostudies-literature
UnknownATF3 plays a key role in Kdo2-lipid A-induced TLR4-dependent gene expression via NF-κB activation.
Not available
S-EPMC2996292 | biostudies-literature
TranscriptomicsHuman Beta-Defensin 3 attenuates the pro-inflammatory effects of KDO2-Lipid A (KLA) at 6 hour
We examine the global effect of hBD3 on transcription in TLR4-stimulated macrophages and for the first time show that hBD3 inhibits the transcription of critical pro-inflammatory genes. Among the repressed genes we detect significant enrichment of groups involved in the positive regulation of NFkapp...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-25871 | biostudies-arrayexpress
TranscriptomicsHuman Beta-Defensin 3 attenuates the pro-inflammatory effects of KDO2-Lipid A (KLA) at 6 hour
We examine the global effect of hBD3 on transcription in TLR4-stimulated macrophages and for the first time show that hBD3 inhibits the transcription of critical pro-inflammatory genes. Among the repressed genes we detect significant enrichment of groups involved in the positive regulation of NFkapp...
ORGANISM(S): Mus musculus 
2012-01-01 | GSE25871 | GEO
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