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ProteomicsMacrophage Proteomic Profiling Reveals Divergent TLR4-Dependent and -Independent Responses to Kdo₂-Lipid A and Lipid IVa
Immortalized mouse macrophages from wild type (WT) were treated with Kdo₂-Lipid A and Lipid IVa under three experimental conditions: (i) extracellular stimulation to assess TLR4-dependent activation with Kdo2 lipid A or lipid-IVa (Extra_Kdo2/Extra_IVa), (ii) direct cytosolic delivery by transfection...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD075293 | Pride
Kdo2-lipid a Lipid iva Tlr4-independent Macrophages Tlr4-dependent Proteomics 
UnknownSynthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages.
Not available
S-EPMC8054148 | biostudies-literature
GenomicsSphingomyelin d18:1/14:0 drives TLR4-dependent metaflammation
Sphingomyelin d18:1/14:0 drives TLR4-dependent metaflammation
PRJNA1529229 | ENA
TranscriptomicsMechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes (Illumina sequencing data)
Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of hundreds of genes, it provides a powerful biological system to elucidate the molecular strategies tha...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-23619 | biostudies-arrayexpress
GenomicsSphingomyelin d18:1/14:0 drives TLR4-dependent metaflammation [SM14]
Sphingomyelin d18:1/14:0 drives TLR4-dependent metaflammation [SM14]
PRJNA1440399 | ENA
UnknownTargeting TLR4-dependent inflammation in post-hemorrhagic brain injury.
Not available
S-EPMC8104018 | biostudies-literature
ProteomicsAge-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses
Host defense against bacterial and fungal infections diminishes with age. In humans, this is thought to be caused in part by a decline in neutrophil responses. However, it remains unclear whether a similar decline in neutrophil function occurs in mice. Here, we show that old mice have a reduced capa...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-20 | PXD035577 | Pride
Tlr4 Phagocytosis Nets Degranulation Neutrophils Ros Aging 
GenomicsRemodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers, thereby enabling signal-dependent transcription factors to bind and function in a cell type-specific manner. Consistent with this model, TLR4 si...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-48759 | biostudies-arrayexpress
UnknownTLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells.
Not available
S-EPMC2905255 | biostudies-literature
UnknownTLR4 in POMC neurons regulates thermogenesis in a sex-dependent manner.
Not available
S-EPMC10205441 | biostudies-literature
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