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ProteomicsMacrophage Proteomic Profiling Reveals Divergent TLR4-Dependent and -Independent Responses to Kdo₂-Lipid A and Lipid IVa
Immortalized mouse macrophages from wild type (WT) were treated with Kdo₂-Lipid A and Lipid IVa under three experimental conditions: (i) extracellular stimulation to assess TLR4-dependent activation with Kdo2 lipid A or lipid-IVa (Extra_Kdo2/Extra_IVa), (ii) direct cytosolic delivery by transfection...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD075293 | Pride
Kdo2-lipid a Lipid iva Tlr4-independent Macrophages Tlr4-dependent Proteomics 
UnknownA TLR4-independent critical role for CD14 in intracellular LPS sensing.
Not available
S-EPMC9376664 | biostudies-literature
GenomicsRemodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers, thereby enabling signal-dependent transcription factors to bind and function in a cell type-specific manner. Consistent with this model, TLR4 si...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-48759 | biostudies-arrayexpress
GenomicsDiet induced obesity is independent of metabolic endotoxemia, Tlr4 signalling and hypothalamic inflammation
Diet induced obesity is independent of metabolic endotoxemia, Tlr4 signalling and hypothalamic inflammation
PRJEB27397 | ENA
ProteomicsPhosphoproteomic profiling of lipopolysaccharide stimulated toll-like receptor pathways in immortalized mouse macrophages
Toll-like receptors (TLRs) are present on the membranes of immune cells such as dendritic cells, macrophages, and natural killer cells. It is essential for the recognition of microbiological components. They trigger both innate and adaptive immune responses against pathogenic microorganisms. Among T...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-30 | PXD064064 | Pride
Tlr4 Lps Data independent acquisition Phosphoproteomics 
UnknownData-Driven Modeling Identifies TIRAP-Independent MyD88 Activation Complex and Myddosome Assembly Strategy in LPS/TLR4 Signaling.
Not available
S-EPMC7246728 | biostudies-literature
TranscriptomicsDiet induced obesity is independent of metabolic endotoxemia, Tlr4 signalling and hypothalamic inflammation
A number of studies have proposed that excess food intake, particularly of high fat diets arise due dysregulation of homeostatic mechanisms regulating neuroendocrine control of appetite and energy balance. Current dogma suggests high fat diets invoke hypothalamic inflammation which reduces hypothala...
ORGANISM(S): Mus musculus 
2018-10-23 | E-MTAB-6929 | biostudies-arrayexpress
UnknownEffects of Sparassis latifolia neutral polysaccharide on immune activity via TLR4-mediated MyD88-dependent and independent signaling pathways in RAW264.7 macrophages.
Not available
S-EPMC9515474 | biostudies-literature
TranscriptomicsMechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes (Illumina sequencing data)
Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of hundreds of genes, it provides a powerful biological system to elucidate the molecular strategies tha...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-23619 | biostudies-arrayexpress
UnknownLipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway.
Not available
S-EPMC9633742 | biostudies-literature
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