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MetabolomicsIAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with amyloidogenic proteins implicated in neurodegeneration, human IAPP (hIAPP) forms membrane permeant toxic oligomers imp...
2020-04-17 | MTBLS951 | MetaboLights
TranscriptomicsMany obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers
Background: The mechanisms of how genetic variants (SNPs) identified in genome-wide association studies act to influence body mass remain unknown for most of these SNPs, which continue to puzzle the scientific community. Recent evidence points to epigenetic and chromatin state of the genome to have ...
ORGANISM(S): Homo sapiens 
2015-09-17 | E-GEOD-73103 | biostudies-arrayexpress
TranscriptomicsDynamic nature of epigenetic patterns observed during the Mars 520-d mission simulation
Interplanetary human spaceflight represents a formidable medical challenge, but also provides a unique platform for investigating human adaptation to extreme environmental changes. Understanding the long-term effects of isolation has relevance in a range of scenarios and it is well recognized that a...
ORGANISM(S): Homo sapiens 
2015-01-14 | E-GEOD-64950 | biostudies-arrayexpress
UnknownSex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.
Not available
S-EPMC10914448 | biostudies-literature
UnknownAssociation of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19.
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S-EPMC10219675 | biostudies-literature
UnknownPaediatric COVID-19 mortality: a database analysis of the impact of health resource disparity.
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S-EPMC9621167 | biostudies-literature
UnknownCOVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study.
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S-EPMC8231091 | biostudies-literature
UnknownThrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry.
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S-EPMC10439444 | biostudies-literature
UnknownImplementation of Recommendations on the Use of Corticosteroids in Severe COVID-19.
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S-EPMC10751594 | biostudies-literature
UnknownAt-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods.
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S-EPMC11252333 | biostudies-literature
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