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ProteomicsPiezo1 integration of vascular architecture with physiological force LC-MSMS
The mechanisms by which physical forces regulate cells to determine complexities of vascular structure and function are enigmatic. Here we show the role the ion channel subunit Piezo1 (FAM38A). Disruption of mouse Piezo1 gene disturbed vascular development and was embryonic lethal within days of the...
ORGANISM(S): Homo sapiens (Human) 
2014-08-08 | PXD001099 | Pride
Shear stress Human Mouse Piezo1 Label-free Phosphoproteomics Huvec Vascular architecture 
ProteomicsSystematic mapping of the adipocyte plasma membrane proteome reveals KCC1 and PIT2 as novel insulin-responsive transporters
The plasma membrane (PM) is a dynamic interface that integrates environmental cues with cellular responses. Insulin is known to remodel the PM primarily by stimulating the translocation of glucose transporter type 4 (GLUT4), but the full scope of this regulation remains poorly defined. Here, we perf...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD068305 | Pride
ProteomicsGlobal redox proteome and phosphoproteome analysis reveals novel mode of Akt regulation
A major knowledge gap in cell signalling is defining the crosstalk between multiple types of post-translational modification (PTM). Here, we take a multi-omic approach (redox proteome, phosphoproteome and total proteome) to delineate signalling networks in adipocytes modulated by reactive oxygen spe...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-12-10 | PXD011525 | Pride
Phosphoproteome Akt Crosstalk Redox proteome 
UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
UnknownSeverity of cardiovascular disease outcomes among patients with HIV is related to markers of inflammation and coagulation.
Not available
S-EPMC4309077 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
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