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MetabolomicsMulti-omics integration reveals Yu-Xue-Bi tablets attenuate rheumatoid arthritis via metabolic reprogramming-mediated Piezo1 suppression

As a systemic chronic inflammatory disease, Rheumatoid arthritis (RA) is characterized by progressive inflammation, bone and cartilage destruction, leading to significant disability, reduced lifespan, and increased mortality. The clinical use of conventional medications including nonsteroidal ant...

2026-01-24 | MTBLS13760 | MetaboLights
ProteomicsPIEZO1 Interactome in HEK cells
The propeller-shaped blades of the PIEZO1 and PIEZO2 ion channels partition into the plasma membrane and respond to indentation or stretching of the lipid bilayer, thus converting mechanical forces into signals that can be interpreted by cells, in the form of calcium flux and changes in membrane pot...
ORGANISM(S): Homo sapiens (Human) 
2024-10-30 | PXD054618 | Pride
Cadm1 Piezo1 Mechanosensation Ion channel 
ProteomicsPIEZO1-related Hereditary Xerocytosis Red Blood Cell proteomics
Proteome of purified erythrocytes from blood samples from patients diagnosed with a PIEZO1-HX based on familial history, non-spherocytic chronic hemolysis, typical osmotic gradient ektacytometry and molecular testing and from healthy donors were analyzed by a label free quantification approach.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031963 | Pride
Erythrocytes   red blood cells   piezo1   xerocytosis   label free   orbitrap velos   human 
ProteomicsPiezo1 integration of vascular architecture with physiological force LC-MSMS
The mechanisms by which physical forces regulate cells to determine complexities of vascular structure and function are enigmatic. Here we show the role the ion channel subunit Piezo1 (FAM38A). Disruption of mouse Piezo1 gene disturbed vascular development and was embryonic lethal within days of the...
ORGANISM(S): Homo sapiens (Human) 
2014-08-08 | PXD001099 | Pride
Shear stress Human Mouse Piezo1 Label-free Phosphoproteomics Huvec Vascular architecture 
TranscriptomicsPIEZO1 activation and signalling is associated with inflammation permissive phenocopy of synovial resident macrophages in early arthritis
Synovial resident macrophages in humans play a key role in maintaining tissue and synovial fluid homeostasis and typically exhibit protective phenotypes. However, at the start of rheumatoid arthritis, macrophages can adopt inflammation-permissive phenotypes. The factors that influence macrophage phe...
ORGANISM(S): Homo sapiens 
2026-01-31 | E-MTAB-15203 | biostudies-arrayexpress
UnknownOxidative modulation of Piezo1 channels.
Not available
S-EPMC12355560 | biostudies-literature
TranscriptomicsPIEZO1 activation and signalling is associated with inflammation permissive phenocopy of synovial resident macrophages in early arthritis
Synovial resident macrophages in humans play a key role in maintaining tissue and synovial fluid homeostasis and typically exhibit protective phenotypes. However, at the start of rheumatoid arthritis, macrophages can adopt inflammation-permissive phenotypes. The factors that influence macrophage phe...
ORGANISM(S): Homo sapiens 
2026-01-31 | E-MTAB-15200 | biostudies-arrayexpress
TranscriptomicsRNA-seq of wildtype and PIEZO1 knockout mice livers to investigate lipid and glucose regulation by the endothelial force sensor PIEZO1
PIEZO1 is a mechanically-activated ion channel that contributes to flow sensing in vascular endothelium. Moreover, deletion of endothelial PIEZO1 was recently found to suppress activation of Notch1 target genes in hepatic microvascular endothelium. Here, because of the liver’s dominant role in lipid...
ORGANISM(S): Mus musculus 
2024-06-29 | E-MTAB-9996 | biostudies-arrayexpress
GenomicsEffect of stimulating PIEZO1 in gastric cancer cells
Effect of stimulating PIEZO1 in gastric cancer cells
PRJNA951217 | ENA
GenomicsTranscriptomic profiling of Piezo1-deficient osteoclast precursors
Transcriptomic profiling of Piezo1-deficient osteoclast precursors
PRJNA1490561 | ENA
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