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TranscriptomicsEffect of 10 or 25 days cortisol treatment on late gestation fetal septum
We have previously shown in sheep that 10 days of modest chronic increase in maternal cortisol result in fetal heart enlargement and Purkinje cell apoptosis. In subsequent studies in which we extended the duration of cortisol infusion (1mg/kg/d) to term, we found a dramatic incidence of stillbirth i...
ORGANISM(S): Ovis aries 
2014-08-07 | E-GEOD-54237 | biostudies-arrayexpress
ProteomicsMicroplastics and algal toxins in mussels: A dual threat to marine health and seafood safety
The molecular responses of marine mussels to contamination with emergent contaminants in marine ecosystems - the biotoxin Okadaic Acidc and Microplastics - was investigated in experiments with live mussels of the species Perna perna. In total 24 independent biological samples, from 4 experimental co...
ORGANISM(S): Perna perna 
2026-07-16 | PXD071829 | Pride
Shotgun proteomics  perna perna  environmental contamination  ecotoxicology 
TranscriptomicsGenomics of the ovine heart ontogeny during the perinatal period
The period of development from the last two weeks of gestation through the first two weeks of life spans a period of great functional and metabolic challenge to the fetal and neonatal lamb heart. Important changes in gene expression occur to meet these challenges. On this study, septa from sheep hea...
ORGANISM(S): Ovis aries 
2015-07-30 | E-GEOD-66725 | biostudies-arrayexpress
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, SCL/TAL1 and FL...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-49664 | biostudies-arrayexpress
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, TAL1, and FLI1)...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-51337 | biostudies-arrayexpress
ProteomicsThe external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth
PknB is an essential serine/threonine protein kinase required for mycobacterial cell division and cell wall biosynthesis. Here we demonstrate that over-expression of the external PknB_PASTA domain in mycobacteria results in delayed regrowth, accumulation of elongated bacteria and increased sensitivi...
ORGANISM(S): Mycobacterium smegmatis 
2018-03-13 | PXD002120 | Pride
Muropeptides Mycobacterium tuberculosis Pasta domain Magnesium Pknb Serine/threonine protein kinase 
GenomicsBromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma (ChIP-Seq)
Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective attenuation of gene expression. Here, we demonstrate that CBP/EP300 bromodomain inhibition preferentially abrogates the viability of multiple mye...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-71909 | biostudies-arrayexpress
ProteomicsTarget deconvolution of SW016789 in human and mouse Beta cells
The target of SW016789 is unknown (PMCID: PMC9225822). This compound was identified in a high-throughput screen for insulin secretion modulators and was subsequently discovered to cause hypersecretory stress in beta cells. A photoaffinity probe was designed, Z629, based upon the structure of SW01678...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2024-03-13 | MSV000094310 | MassIVE
UnknownComparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP).
Not available
S-EPMC5861160 | biostudies-literature
UnknownWhole-genome sequencing reveals host factors underlying critical COVID-19.
Not available
S-EPMC9259496 | biostudies-literature
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