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To define the specific function of Pax3:Foxo1a in G2/M stage, we compared whole mRNA expressions of mouse alveolar rhabdomyosarcoma tumor cells in G2/M stage (4N) with or without Pax3:Foko1a knockdown (si_YFP or si_control). The exerimental plan will include triplicate samples for sorted cells at G1...
ORGANISM(S): Mus musculus 
The highly aggressive muscle cancer alveolar rhabdomyosarcoma (ARMS) is one of the most common soft tissue sarcoma of childhood, yet the outcome for unresectable and metastatic disease is dismal and unchanged for nearly 3 decades. To better understand the pathogenesis of this disease and to facilita...
ORGANISM(S): Mus musculus 
Background Small intestine and liver greatly contribute to whole body lipid, cholesterol and phospholipid metabolism but to which extent cholesterol and phospholipid handling in these tissues is affected by high fat Western-style obesogenic diets remains to be defined. We therefore quantified choles...
ORGANISM(S): Mus musculus 
We have previously shown in sheep that 10 days of modest chronic increase in maternal cortisol result in fetal heart enlargement and Purkinje cell apoptosis. In subsequent studies in which we extended the duration of cortisol infusion (1mg/kg/d) to term, we found a dramatic incidence of stillbirth i...
ORGANISM(S): Ovis aries 
Fetuses respond to transient hypoxia (a common stressor in utero) with cellular responses that are appropriate for promoting survival of the fetus. The present experiment was performed to identify the acute genomic responses of the fetal hypothalamus to transient hypoxia. Three fetal sheep were ex...
ORGANISM(S): Ovis aries 
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