Sort   by:  
 Page size 
TranscriptomicsA Gene Expression Network Model of Type 2 Diabetes Links Cell Cycle
Insulin resistance is necessary but not sufficient for the development of type 2 diabetes. Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by increasing insulin production through an expansion of beta-cell mass or increased insulin secretion. Communication betwe...
ORGANISM(S): Mus musculus 
2008-03-14 | E-GEOD-10785 | biostudies-arrayexpress
GenomicsH3K4me3 ChIP in multiple myeloma MM1S cells in the presence and absence of KDM5-C70
In this experiment we demonstrate the use of an inhibitor of the KDM5 family of histone demethylases, KDM5-C70, on H3K4me3 marks in the multiple myeloma cell line MM1S. KDM5-C70 increases H3K4me3 in a global fashion across the genome. Examination of H3K4me3 mark across MM1S cells treated with eithe...
ORGANISM(S): Homo sapiens 
2016-04-05 | E-GEOD-78206 | biostudies-arrayexpress
TranscriptomicsRNA-seq alignment to individualized genomes
The source of most errors in RNA sequencing (RNA-seq) read alignment is in the repetitive structure of the genome and not with the alignment algorithm. Genetic variation away from the reference sequence exacerbates this problem causing reads to be assigned to the wrong location. We developed a metho...
ORGANISM(S): Mus musculus 
2014-06-10 | E-GEOD-45684 | biostudies-arrayexpress
ProteomicsSample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression
Targeted proteomics enables hypothesis-driven research by measuring the cellular expression of protein cohorts related by function, disease, or class after perturbation. Here, we present a pathway-centric approach and an assay builder resource for targeting entire pathways of proteins selected from ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2022-08-11 | MSV000090110 | MassIVE
TranscriptomicsmicroRNA analysis of infantile hemangioma, lymphatic malformation, and skin
Surgical specimens from children with infantile hemangioma or lymphatic malformations, as well as healthy appearing adjacent skin, were analyzed by microarray analysis of microRNA expression. Unsupervised hierarchical clustering was performed to identify microRNAs that were differentially expressed ...
ORGANISM(S): Homo sapiens 
2015-05-22 | E-GEOD-69136 | biostudies-arrayexpress
ProteomicsTarget deconvolution of SW016789 in human and mouse Beta cells
The target of SW016789 is unknown (PMCID: PMC9225822). This compound was identified in a high-throughput screen for insulin secretion modulators and was subsequently discovered to cause hypersecretory stress in beta cells. A photoaffinity probe was designed, Z629, based upon the structure of SW01678...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2024-03-13 | MSV000094310 | MassIVE
UnknownStructural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study.
Not available
S-EPMC5837616 | biostudies-literature
UnknownA systems-level analysis highlights microglial activation as a modifying factor in common epilepsies.
Not available
S-EPMC8983060 | biostudies-literature
UnknownA WORLDWIDE ENIGMA STUDY ON EPILEPSY-RELATED GRAY AND WHITE MATTER COMPROMISE ACROSS THE ADULT LIFESPAN.
Not available
S-EPMC10942350 | biostudies-literature
UnknownArtificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study.
Not available
S-EPMC8346685 | biostudies-literature
Sort   by:  
 Page size