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ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery. Here we probe the effects of catalytic inhibition on the proximity of CAMKK2. The experiment was supervised by Sabrina Keller and Viviane Reber. This project is part of the IMI ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058418 | Pride
Bioid 
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery. Here we probe the effects of catalytic inhibition on the proximity of CAMKK2. The experiment was supervised by Sabrina Keller and Viviane Reber. This project is part of the IMI ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058412 | Pride
Bioid 
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery. Here we probe the effects of catalytic inhibition of CAMKK2 on the proximity of PRKAA1. The experiment was supervised by Sabrina Keller and Viviane Reber. This project is part o...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058471 | Pride
Bioid 
MetabolomicsMolecular structural diversity of mitochondrial cardiolipins
Current strategies used to quantitatively describe the biological diversity of lipids by mass spectrometry are often limited in assessing the exact structural variability of individual molecular species in detail. A major challenge is represented by the extensive isobaric overlap present among lipid...
2021-01-11 | MTBLS636 | MetaboLights
MetabolomicsPhospholipid acyl chain diversity controls the tissue-specific assembly of mitochondrial cardiolipins

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its side chain configurations are tissue-specific, functionally important and generated via post-biosynthetic remodeling. However, this process lacks the necessary specificit...

2020-05-22 | MTBLS1446 | MetaboLights
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of Thalidomide
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-...
ORGANISM(S): Homo sapiens (Human) 
2023-04-26 | PXD041097 | Pride
Eubopen crbn thalidomide 
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of Lenalidomde
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-...
ORGANISM(S): Homo sapiens (Human) 
2023-04-26 | PXD041200 | Pride
Eubopen crbn lenalidomide 
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of CC-885
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-...
ORGANISM(S): Homo sapiens (Human) 
2023-04-26 | PXD041128 | Pride
Eubopen crbn cc-885 
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of Iberdomide
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory or PROTAC drugs are a prime example for proximity-...
ORGANISM(S): Homo sapiens (Human) 
2023-04-26 | PXD041081 | Pride
Eubopen crbn iberdomide 
UnknownA first update on mapping the human genetic architecture of COVID-19.
Not available
S-EPMC9352569 | biostudies-literature
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