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TranscriptomicsTranscription profiling of blood cells from hypertriglyceridemic men treated with docosahexaenoic acid shows suppression of LDLR and OLR1 gene expression.
Previously published results from our double-blind, placebo-controlled parallel study with docosahexaenoic acid (DHA) supplementation (3 g/d, 90 d) to hypertriglyceridemic men (39-66yr) showed that DHA reduced several risk factors for cardiovascular disease (CVD), including the plasma concentration ...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-20114 | biostudies-arrayexpress
TranscriptomicsInterplay of host microbiota, genetic perturbations, and inflammation promote local development of intestinal neoplasms in mice
The preferential localization of some neoplasms, such as serrated polyps, in specific areas of the intestine suggests that non-genetic factors may be important for their development. To test this hypothesis, we took advantage of transgenic mice that expressed HB-EGF throughout the intestine, but dev...
ORGANISM(S): Mus musculus 
2014-02-12 | E-GEOD-47735 | biostudies-arrayexpress
GenomicsRare Mendelian Disease in Old Order Amish and Mennonite Patients

The Clinic for Special Children (CSC) has integrated biochemical and molecular methods into a rural pediatric practice serving Old Order Amish and Mennonite (Plain) children. Among the Plain people, we have used single nucleotide polymorphism (SNP) microarrays to genetically map recessive disorde...

phs000623.v1.p1 | EGA
TranscriptomicsFunctional Evidence Implicating Chromosome 7q22 Haploinsufficiency in Myelodysplastic Syndrome Pathogenesis
Purpose: 5A3+/del mice, which have a heterozygous germ line deletion of a 2-Mb interval of chromosome band 5A3 syntenic to a commonly deleted segment of human 7q22, exhibit hematopoietic stem cell (HSC) abnormalities that may contribute to myelodysplastic syndrome (MDS) pathogenesis. These defects a...
ORGANISM(S): Mus musculus 
2015-09-09 | E-GEOD-72811 | biostudies-arrayexpress
TranscriptomicsInterplay of host microbiota, genetic perturbations, and inflammation promote local development of intestinal neoplasms in mice
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-02-12 | E-GEOD-47736 | biostudies-arrayexpress
ProteomicsRaw data for the characterization of a Pseudomonas putida malonyl-ACP decarboxylase
Raw data for top down LCMS for detecting modifications on recombinant proteins, and GCMS for fatty acid methyl ester analysis. Sample nomenclature is summarized in the Powerpoint and PDF files. Details of experiments are given in the associated manuscript.
ORGANISM(S): Pseudomonas Putida Kt2440 (ncbitaxon:160488) 
MSV000090294 | MassIVE
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