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MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
ProteomicsComprehensive respiratory phenomics across multiple models of mitochondrial protein hyperacylation reveals a paradoxically marginal impact on bioenergetics
Acyl CoA metabolites derived from catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translation modifications (PTMs). Mass spectrometry-based detection of thousands of acyl-PTMs scattered throughout the proteome has established...
ORGANISM(S): Mus Musculus (mouse) 
2019-02-07 | PXD011375 | JPOST Repository
UnknownKi67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance).
Not available
S-EPMC5455353 | biostudies-literature
UnknownSensorimotor Behavior in Individuals With Autism Spectrum Disorder and Their Unaffected Biological Parents.
Not available
S-EPMC11929603 | biostudies-literature
UnknownEvaluating whole-genome expression differences in idiopathic and diabetic adhesive capsulitis.
Not available
S-EPMC8665043 | biostudies-literature
UnknownComplete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma.
Not available
S-EPMC4872006 | biostudies-literature
UnknownSocial Aspects of the Workplace Among Individuals With Bipolar Disorder.
Not available
S-EPMC5798466 | biostudies-literature
UnknownUse of hare bone for the manufacture of a Clovis bead.
Not available
S-EPMC10844228 | biostudies-literature
UnknownProteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease.
Not available
S-EPMC11991917 | biostudies-literature
UnknownEvaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial.
Not available
S-EPMC7878429 | biostudies-literature
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