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ProteomicsCentral nervous system involvement of acute lymphoblastic leukemia depends on mRNA translation and complement component 3
Central nervous system (CNS) dissemination of B-precursor acute lymphoblastic leukemia (B-ALL) has a poor prognosis and remains a therapeutic challenge with few recent advances in therapy. Leptomeningeal disease is particularly common in the high risk subgroup of KMT2A-rearranged B-ALL (KMT2A-r B-AL...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD022411 | Pride
Lc-ms Leukemia Lfq 
UnknownAt-home Breast Oncology care Delivered with EHealth solutions (ABODE) study protocol: a randomised controlled trial.
Not available
S-EPMC12067776 | biostudies-literature
UnknownSIRPαFc treatment targets human acute myeloid leukemia stem cells.
Not available
S-EPMC7776262 | biostudies-literature
ProteomicsmiR-126 Governs Human Leukemia Stem Cell Quiescence and Therapeutic Resistance
In acute myeloid leukemia (AML), leukemia stem cells (LSC) play a central role in disease progression and recurrence due to their intrinsic capacity for self-renewal and chemotherapy resistance. Whereas epigenetic mechanisms balance normal blood stem cell self-renewal and fate decisions, mutation an...
ORGANISM(S): Homo sapiens (Human) 
2016-03-31 | PXD001994 | Pride
Aml Global proteomics Scx Stem cells Mir126 
UnknownAlu insertion variants alter gene transcript levels.
Not available
S-EPMC8647820 | biostudies-literature
UnknownClinical Utility of Next-generation Sequencing in the Management of Myeloproliferative Neoplasms: A Single-Center Experience.
Not available
S-EPMC6745993 | biostudies-literature
UnknownTerm Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin.
Not available
S-EPMC8546705 | biostudies-literature
ProteomicsmiR-125a Confers Multi-Lineage Long-Term Repopulating Stem Cell Activity to Murine and Human Hematopoietic Progenitors
Umbilical cord blood (CB) is a non-invasive, convenient and broadly used source of hematopoietic stem cells (HSCs) for allogeneic stem cell transplantation. However, limiting numbers of HSCs remain a major constraint for its clinical application. One feasible option would be to expand HSCs to improv...
ORGANISM(S): Homo sapiens (Human) 
2017-01-11 | PXD003931 | Pride
Hematopoiesis Stem cell proteomics Microrna Low-cell input 
GenomicsNational Eye Institute Glaucoma Human Genetics Collaboration (NEIGHBOR) Consortium Glaucoma Genome-Wide Association Study

This is a case-control study of primary open angle glaucoma (POAG). POAG is an intraocular pressure (IOP) related progressive optic neuropathy that ultimately leads to blindness. For this study we have formed a collaborative consortium contributing 2170 POAG cases and 2347 controls with a unified...

phs000238.v1.p1 | EGA
UnknownThe mutational landscape of accelerated- and blast-phase myeloproliferative neoplasms impacts patient outcomes.
Not available
S-EPMC6199664 | biostudies-literature
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