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TranscriptomicsCDKN1B encoding the cyclin-dependent kinase inhibitor 1B (p27) is located in the minimally deleted region of 12p abnormalities in myeloid malignancies and its low expression is a favorable prognostic marker in acute myeloid leukemia
Alterations of the short arm of chromosome 12 (12p) occur in various hematological malignancies and ETV6 and CDKN1B, which are located on 12p, have been implicated as leukemogenic genes of interest. Design and Methods: We selected 7 patients with myeloid malignancies and small 12p deletions by FISH ...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-27832 | biostudies-arrayexpress
TranscriptomicsChange in gene expression in Chlamydomonas reinhardtii upon heat shock
This was an accompanying experiment. Previously, the expression of genes hsp70A and hsp70B had been established as being tetrapyrrole-dependent (Kropat et al., 1997, 2000). Since both are well-known heat-shock proteins, we performed a one-step heat shock treatment by shifting the temperatures from 2...
ORGANISM(S): Chlamydomonas reinhardtii 
2011-03-02 | E-GEOD-20859 | biostudies-arrayexpress
TranscriptomicsMultilineage dysplasia does not influence prognosis in patients with CEBPA mutated AML supporting the WHO proposal to classify these patients as a unique entity
By WHO 2008, CEBPA-mutated AML became a provisional subentity, but it remains to be clarified how CEBPAmut AML with multilineage dysplasia (MLD; ?50% dysplastic cells in 2-3 lineages) but no other MDS-related feature should be classified. We investigated 108 CEBPAmut AML (15.7-87.6 years) for the im...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-33223 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Multilineage Dysplasia (MLD) in AML correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance
Full Title: Multilineage Dysplasia (MLD) in AML correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: A comparison of 408 cases classified as “AML not otherwise specified” or “AML with myelodysplasia-related changes” ...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-21261 | biostudies-arrayexpress
ProteomicsCompartment resolved reference map from highly purified naive, activated, effector and memory CD8+ cells
Differentiation of CD8+ T lymphocytes into effector and memory cells is key for an adequate immune response and relies on complex interplay of pathways that convey signals from cell surface to nucleus. In this study, we fractionated four CD8+ T cell subtypes; naïve, recently activated effector, eff...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-02-29 | MSV000079540 | MassIVE
TranscriptomicsA comparative transcriptomics approach unveils networks of activity-driven neuronal gene expression
Primary cultured hippocampal neurons were infected with lentiviral particles bearing constitutively active versions of the transcription factors CREB, SRF, EGR1 and FOS to define the downstream genetic program associated with each of these paradigmatic transcription factors in neurons. For CREB, we ...
ORGANISM(S): Mus musculus 
2011-11-19 | E-MEXP-3167 | biostudies-arrayexpress
TranscriptomicsAcute myeloid leukemia with CEBPA double-mutations harbors in 76.8% of cases concomitant molecular mutations with TET2 and GATA2 alterations demonstrating strong prognostic impact
Acute myeloid leukemia (AML) with CEBPA mutations is determined as provisional entity in the current WHO. A difference in clinical outcome between single- (sm) and double-mutated (dm) cases has been reported, whereupon dm cases were shown to be associated with longer overall survival (OS). The occur...
ORGANISM(S): Homo sapiens 
2013-04-20 | E-GEOD-42064 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesenchymal stem cells to determine changes over the course of cellular aging
To determine gene expression changes during in vitro senescence of MSC we have analyzed differential expression of the corresponding early passage (P2) and senescent passage (PX). There were global changes in the gene expression profile that were reproducible in three independent donor samples. Expe...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-9593 | biostudies-arrayexpress
TranscriptomicsChIP-seq against BZLF1 in DG75 cells (EBV-negative, human Burkitt lymphoma cell line)
The parental DG75 cell line is EBV negative and cannot express the viral BZLF1 protein, thus, this set of experiments served as a negative control. After ChIP, peaks were identified in both the human and viral (EBV (Human Herpesvirus 4) genome KF717093.1) genome. Only few peaks were identified. Expe...
ORGANISM(S): Homo sapiens 
2019-04-05 | E-MTAB-7821 | biostudies-arrayexpress
TranscriptomicsMultilineage dysplasia and AML with mutated nucleophosmin
Multilineage dysplasia (MLD) has no impact on biological, clinico-pathological and prognostic features of AML with mutated nucleophosmin (NPM1) NPM1-mutated AML is a provisional entity in the WHO-2008 classification of myeloid neoplasms. The significance of concomitant multilineage dysplasia (MLD) i...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-18018 | biostudies-arrayexpress
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