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Proteomics,MultiomicsElectrophilic stress induced by itaconate and its derivatives regulates ATF3-IKBZ inflammatory axis independently of Nrf2 induction
Metabolic regulation recently emerged as a novel powerful principle guiding immune responses. The natural metabolite itaconate and its membrane permeable derivative dimethyl itaconate (DI) were recently shown to selectively inhibit a subset of cytokines during macrophage activation, yet the precise ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-02-25 | MSV000082101 | MassIVE
UnknownDephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor.
Not available
S-EPMC8892339 | biostudies-literature
TranscriptomicsFunctional and Molecular Single-Cell Analyses Implicate PRDM14 in the Initiation of a Novel B-1 Cell Malignancy - Cut and Run experiments
Molecular mechanisms underlying high-risk subtypes of leukemia remain elusive. PR domain-containing 14 (Prdm14) is a potent oncogene implicated in the initiation of many cancers, including leukemia. Here, we interrogate the heterogeneity of Prdm14-expressing cell types in a mouse model of T-cell acu...
ORGANISM(S): Mus musculus 
2024-06-26 | E-MTAB-13159 | biostudies-arrayexpress
GenomicsTE-associated chromatin variation in mice livers
Chromatin accessibility is a hallmark of active regulatory function in the genome and variation of chromatin accessibility across individuals has been shown to contribute to complex traits and disease susceptibility. However, the mechanisms responsible for chromatin variation among different individ...
ORGANISM(S): Mus musculus 
2016-07-14 | E-GEOD-75770 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of human skeletal muscle samples from metabolic syndrome patients following defined exercise (STRRIDE study)
STRRIDE is an exercise intervention study of different doses and intensities in overweight women and men with the metabolic syndrome. We profiled biopsies from 3 female and 3 male STRRIDE subjects in the “high” exercise group (2,200 kCal/wk). Muscle biopsies were profiled at entry (0h), and afte...
ORGANISM(S): Homo sapiens 
2007-08-02 | E-GEOD-1295 | biostudies-arrayexpress
Transcriptomics3'-UTR-seq of Mus musculus female and male hypothalamus across the pubertal transition
The hypothalamus is a functionally and cellularly complex tissue controlling many developmental processes, including puberty. While key hormonal aspects of puberty regulation in the hypothalamus are well established, understanding the genes, cell-types, and epigenetic mechanisms underlying and regul...
ORGANISM(S): Mus musculus 
2023-04-01 | E-MTAB-12340 | biostudies-arrayexpress
UnknownIncreasing LFA-1 Expression Enhances Immune Synapse Architecture and T Cell Receptor Signaling in Jurkat E6.1 Cells.
Not available
S-EPMC8343233 | biostudies-literature
TranscriptomicsRegulation of nucleosome landscape and transcription factor binding at enhancers by BRG1
Enhancers of transcription activate transcription via binding of sequence-specific transcription factors to their target sites in chromatin. In this report, we identify GATA1-bound enhancers genome-wide and find a global reorganization of the nucleosomes at these enhancers during differentiation of ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-26501 | biostudies-arrayexpress
TranscriptomicsClinical, Molecular and Genetic Validation of a Murine Orthotopic Xenograft Model of Pancreatic Adenocarcinoma using Fresh Human Specimens
This project describes the establishment and validation of a murine orthotopic xenograft model using fresh human tumor samples that recapitulates the critical components of human pancreatic adenocarcinoma. The authors discuss the proven and theoretical advantages of the model as well as future tran...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-46385 | biostudies-arrayexpress
TranscriptomicsCombined multiphoton live-cell imaging and molecular systems approaches reveal mosaic contribution of dynamic transiently signaling INPs to the adult Dentate Gyrus NSC niche
Here we directly compare for the first time how the longstanding static model of mouse Dentate Gyrus (DG) development compares with a comprehensive high-resolution live-cell multiphoton (live-MPM) imaging approach. We took advantage of multiple fluorescent protein-based cell-type specific reporters ...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-50148 | biostudies-arrayexpress
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