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TranscriptomicsRecombination initiation maps of individual human genomes
DNA double-strand breaks (DSBs) are introduced in meiosis to initiate recombination and to generate crossovers, the reciprocal exchanges of genetic material between parental chromosomes. Here we present the first high-resolution map of meiotic DSBs in individual human genomes. Comparing DSB maps bet...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-59836 | biostudies-arrayexpress
TranscriptomicsE. coli response to MMC
Changes in gene expression after treatment of E. coli cultures with mitomycin C were assessed using gene array technology. Unexpectedly, a large number of genes (nearly 30% of all genes) displayed significant changes in their expression level. Analysis and classification of expression profiles of t...
ORGANISM(S): Escherichia coli 
2010-06-05 | E-GEOD-33 | biostudies-arrayexpress
TranscriptomicsGene expression in mouse ovary and testis
To investigate the genomic distribution of genes with sex- biased expression patterns in mice we analyzed the chromosomal distribution of genes preferentially expressed in sexually dimorphic tissues such as testis and ovary.
ORGANISM(S): Mus musculus 
2004-03-26 | E-GEOD-1138 | biostudies-arrayexpress
TranscriptomicsRNA-Seq and RNA Polymerase II ChIP-Seq of mouse spermatogenesis
To characterize gene expression in spermatogenesis we sequenced eight mRNA samples from testes of juvenile mice aged between 6 and 38 days post partum. We then classified gene expression profiles and found over 1,000 meiotically-expressed protein-coding genes that have not been previously reported i...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-44346 | biostudies-arrayexpress
TranscriptomicsSex-dependent RNA expression in opossum brain and liver.
To compensate for the increased dosage of X chromosomes in females one of the two X chromosomes is inactivated in eutherian mammals in an Xist-dependent manner. Xist is, however, not found in metatherians. Here we describe long non-coding RNA Rsx (RNA-on-the-silent X) that exhibits properties consis...
ORGANISM(S): Monodelphis domestica 
2012-06-11 | E-GEOD-36861 | biostudies-arrayexpress
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