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TranscriptomicsTranscription profiling of mouse P5 cerebellum to investigate conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of neuroblastoma
Identification of common mechanisms underlying organ development and primary tumor formation should yield new insights into tumor biology and facilitate the generation of relevant cancer models. We have developed a novel method to project the gene expression profiles of medulloblastomas (MBs)—human ...
ORGANISM(S): Mus musculus 
2009-01-30 | E-GEOD-14514 | biostudies-arrayexpress
TranscriptomicsAn EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium
Normal human bronchial epithelial cells were studied under four different conditions: control, pressure 30 cmH2O, AG1478 (1 microM), and pressure plus AG1478 at 1, 3, and 8 hours, all in the absence of exogenous EGF. Keywords: Normal human bronchial epithelial cells. Time series under 4 different s...
ORGANISM(S): Homo sapiens 
2009-12-15 | E-GEOD-19500 | biostudies-arrayexpress
TranscriptomicsIdentification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach perspective of human cancers.
Swiss-Webster B mouse postnatal day 4-5 primary cerebellar culture (pooled from litter mates) treated with sonic hedgehog (Shh), controls (veh), growth arrested (arrest), cycloheximide (cyc) for 1, 3 and 24 hours. Different treatment conditions with biological replicates. Mouse cerebellar granule ce...
ORGANISM(S): Mus musculus 
2013-09-06 | E-GEOD-50606 | biostudies-arrayexpress
TranscriptomicsRegulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin.
Analysis of the transcriptome of mononuclear side population (SP) and main population (MP) cells of human fetal skeletal muscle from 12 human subjects of gestational age 14-18 weeks. Total RNA was extracted and profiled from 12 human fetal skeletal muscle side population (SP) cells and 10 correspond...
ORGANISM(S): Homo sapiens 
2011-01-26 | E-GEOD-26869 | biostudies-arrayexpress
TranscriptomicsDefective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia.
Transcriptome profile of highly purified multipotential (P), erythroid (E), and myeloid (M) bone marrow progenitors from three RPS19 mutated Diamond-Blackfan anemia and six control human subjects. Two group comparison of sex and age matched subjects. Bone marrow progenitors, gene expression profilin...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-41599 | biostudies-arrayexpress
TranscriptomicsFeedback amplication of fibrosis through matrix stiffening and COX-2 suppression
We tested the hypothesis that increasing matrix stiffness on which normal human lung fibroblasts are grown promotes the expression of a fibrogenic cellular transcriptomic program. Keywords: Human lung fibroblast, matrix stiffness, PTGS2, COX-2, Prostaglandin E2 Total RNA extracted from normal human...
ORGANISM(S): Homo sapiens 
2010-07-15 | E-GEOD-22011 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of zebrafish mononuclear myogenic cells (zMNCs) during myogenic differentiation
Analysis of the transcriptome of zebrafish mononuclear myogenic cells (zMNCs) during myogenic differentiation. The main goal is to identify the similarities of zMNC myogenic differentiation with that of mammalian myoblast differentiation. Critical time points were used to identify a switch from the ...
ORGANISM(S): Danio rerio 
2010-04-07 | E-GEOD-19754 | biostudies-arrayexpress
TranscriptomicsIn utero allergen exposure reprograms primary developmental patterns of lung gene expression and influences respiratory phenotype in rat models of asthma susceptibility.
Transcriptome of whole lung of rat from 3 genetic strains, 3 postnatal time points and 2 exposures (saline versus ovalbumin) in (mainly) 4 replicate measurements per condition. Total RNA obtained from whole lung of rat from 3 genetic strains, 3 postnatal time points and 2 exposures (saline versus ov...
ORGANISM(S): Rattus norvegicus 
2012-10-11 | E-GEOD-32622 | biostudies-arrayexpress
TranscriptomicsGenetic Influences on Asthma Susceptibility in Developing Lung
Whole transcriptome assay of whole lung of rat from 3 genetic strains (Lewis, Fisher, Brown Norway) at 3 postnatal time points (postnatal days 1, 7, 14). Total RNA obtained from whole lung of rat from 3 genetic strains and 3 postnatal time points in (mainly) quadruplicate measurements per strain and...
ORGANISM(S): Rattus norvegicus 
2010-06-24 | E-GEOD-19666 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human developing lung
We decompose the genome-wide expression patterns in 38 embryonic human lung (53-154 days post conception/dpc) into their independent, dominant directions of transcriptomic sample variation in order togain global insight of the developing human lung transcriptome.The characteristic genes and their co...
ORGANISM(S): Homo sapiens 
2009-09-26 | E-GEOD-14334 | biostudies-arrayexpress
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