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MetabolomicsCE-MS Metabolomic and LC-MS Proteomic Analyses of Breast Cancer Exosomes Reveal Alterations in Purine and Carnitine Metabolism

A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased ...

2024-11-14 | MTBLS11190 | MetaboLights
ProteomicsComprehensive Proteomic Profiling of Breast Cancer-Derived Small Extracellular Vesicles Unveiled PXDN and GGT5 as Novel Protein Markers Implicated in Oncogenic Signaling Networks
Breast cancer (BC) is the most prevalent cancer and the second leading cause of cancer-related mortality among Canadian women. Early detection and treatment can significantly improve survival rates. The potential use of small extracellular vesicles (sEVs) as biomarkers for early BC diagnosis has gai...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD062276 | Pride
Human Small extracellualr vesicles Breast cancer Mcf-10a Ggt5 Mda-mb-231 Pxdn Lc-ms 
ProteomicsMetabolomic and Proteomic Analysis of Breast Cancer Exosomes Reveals Alterations in Purine and Carnitine Metabolism
A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased pur...
ORGANISM(S): Homo sapiens (Human) 
2025-03-25 | PXD056161 | Pride
Metabolomics Breast cancer Capillary electrophoresis-mass spectrometry Proteomics 
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