Sort   by:  
 Page size 
MetabolomicsMetabolomic profiling of mouse kidney in a model of Cardiovascular-Kidney-Metabolic syndrome

Cardiovascular-kidney-metabolic (CKM) syndrome is a complex systemic disorder. In this study, we developed a urea-activated nanoparticle (T-PAAD NP) for targeted delivery of Empagliflozin to the renal S1 segment. Untargeted GC-MS-based metabolomics was performed to characterize metabolic reprogra...

2026-03-21 | MTBLS13988 | MetaboLights
MetabolomicsTissue, urine and serum NMR metabolomics dataset from a 5/6 nephrectomy rat model of chronic kidney disease

Serum, urine and tissue from a rat model of chronic kidney disease (CKD) were analysed using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics methods, and compared with samples from sham operated rats. Both urine and serum were sampled at multiple timepoints, and the results have ...

2020-11-16 | MTBLS2052 | MetaboLights
MetabolomicsMetabolomic profiling of mouse heart in a model of Cardiovascular-Kidney-Metabolic syndrome

Cardiovascular-kidney-metabolic (CKM) syndrome is a complex systemic disorder. In this study, we developed a urea-activated nanoparticle (T-PAAD NP) for targeted delivery of Empagliflozin to the renal S1 segment. Untargeted GC-MS-based metabolomics was performed to characterize metabolic reprogra...

2026-03-21 | MTBLS13991 | MetaboLights
MetabolomicsUntargeted gas chromatography–mass spectrometry-based metabolomics analysis of kidney and liver tissue from the Lewis Polycystic Kidney rat
Polycystic kidney disease (PKD) encompasses a spectrum of inherited disorders that lead to end-stage renal disease (ESRD). There is no cure for PKD and current treatment options are limited to renal replacement therapy and transplantation. A better understanding of the pathobiology of PKD is needed ...
2023-01-26 | MTBLS748 | MetaboLights
MetabolomicsMetabolic Footprinting of a Clear Cell Renal Cell Carcinoma in vitro Model for Human Kidney Cancer Detection
A protocol for harvesting and extracting extracellular metabolites from an in vitro model of human renal cell lines was developed to profile the exometabolome by means of a discovery-based metabolomics approach using ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass sp...
2018-11-14 | MTBLS737 | MetaboLights
Metabolomicstargeted metabolomics of rat's kidney
Podophyllotoxin (PPT) exhibits limited clinical utility due to its nephrotoxicity, and its underlying mechanisms remain poorly understood. This study employs the toxicological evidence chain (TEC) framework and integrated multi-omics analyses to investigate the potential involvement of the microbiot...
2026-06-28 | MTBLS14869 | MetaboLights
MetabolomicsKidney Tissue Targeted Metabolic Profiling of Unilateral Ureteral Obstruction Rats by NMR
Renal interstitial fibrosis is a common pathological process in the progression of kidney disease. A nuclear magnetic resonance (NMR) based metabolomics approach was used to analyze the kidney tissues of renal interstitial fibrosis (RIF) rats, induced by unilateral ureteral obstruction (UUO). The co...
2017-10-09 | MTBLS361 | MetaboLights
MetabolomicsTubular insulin-induced gene 1 deficiency promotes NAD+ consumption and exacerbates kidney fibrosis

Profibrotic proximal tubular (PT) were identified as a unique phenotype of PTCs in renal fibrosis by single-cell RNA sequencing (scRNA-seq). Controlling the process of renal fibrosis requires understanding how to manage the S1 subset's branch to the S3 subset rather than to the profibrotic PT sub...

2024-05-28 | MTBLS9985 | MetaboLights
MetabolomicsGeographic variation of mutagenic exposures in kidney cancer genomes

International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden1. This pertains to clear cell renal cell carcinoma (ccRCC), fo...

2024-03-26 | MTBLS9394 | MetaboLights
MetabolomicsA Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease
Identification of chronic kidney disease patients at risk of progressing to end-stage renal disease (ESRD) is essential for treatment decision-making and clinical trial design. Here, we explored whether proton nuclear magnetic resonance (NMR) spectroscopy of blood plasma improves the currently best ...
2019-07-26 | MTBLS798 | MetaboLights
Sort   by:  
 Page size