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ProteomicsEpigenetic mechanisms to propagate histone acetylation by p300/CBP
Histone acetylation is important for the activation of gene transcription but little is known about its direct ‘read/write’ mechanisms. Here, we report cryo-electron microscopy structures in which a p300/CBP multidomain monomer recognizes histone H4 N-terminal tail (NT) acetylation (ac) in a nucleos...
ORGANISM(S): Homo sapiens (Human) 
2023-05-08 | PXD040835 | Pride
P300/cbp Histone Acetylation 
ProteomicsThe methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes
Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3- methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-11-23 | PXD022067 | Pride
Metylation histidine mettl9 
UnknownAccumulation of arachidonic acid-containing phosphatidylinositol at the outer edge of colorectal cancer.
Not available
S-EPMC4951683 | biostudies-literature
UnknownAcute hepatitis C in HIV-1 infected Japanese Cohort: single center retrospective cohort study.
Not available
S-EPMC4063971 | biostudies-literature
UnknownCase report: Genomic analysis of a therapy-related chronic myelomonocytic leukemia with KMT2A rearrangement that progressed to acute myeloid leukemia with acute promyelocytic leukemia-like features.
Not available
S-EPMC9981998 | biostudies-literature
ProteomicsProteome analysis of human postmortem brain tissues in tauopathies, including corticobasal degeneration, progressive supranuclear palsy, and Alzheimer's disease
Tauopathies are a group of neurodegenerative diseases characterised by the abnormal accumulation of tau protein within neural and glial cells. The molecular mechanisms of tauopathies remain poorly understood. To identify proteins whose abundance is altered by the disease group, we performed a proteo...
ORGANISM(S): Homo Sapiens (human) 
2026-05-09 | PXD072806 | JPOST Repository
UnknownA prospective cohort study of neighborhood stress and ischemic heart disease in Japan: a multilevel analysis using the JACC study data.
Not available
S-EPMC3128019 | biostudies-literature
UnknownGenome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
Not available
S-EPMC3484650 | biostudies-literature
UnknownPOGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33.
Not available
S-EPMC6331557 | biostudies-literature
ProteomicsProSeAM SILAC MS screening for METTL9 substrates
Click chemistry based substrates screening for METTL9 in Mettl9 KO MEF cells.
ORGANISM(S): Mus Musculus (mouse) 
2020-11-19 | PXD016823 | JPOST Repository
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