Sort   by:  
 Page size 
Proteomicsp97/VCP inhibition radiosensitises cancer cells through excessive MRE11-dependent DNA end resection
Cancer cells are under constant proteotoxic stress and have an increased genomic instability. They therefore rely on upregulation of protein homeostasis and the DNA damage response (DDR) for survival. The ubiquitin-dependent ATPase p97 is a central component of the ubiquitin-proteasome degradation s...
ORGANISM(S): Homo sapiens (Human) 
2021-05-18 | PXD016279 | Pride
Single-strand annealing Bladder cancer Dna double-strand break repair Proteasomal degradation Dna damage Ubiquitin Cb-5083 Homologous recombination Mre11 P97 
GenomicsData Access Committee
Data Access Committee EGAC00001000186
EGAC00001000186 | EGA
GenomicsGenome wide association study for Bladder Cancer Risk

This study funded by the National Cancer Institute (NCI) involves conducting a genome-wide association study of common genetic variants to identify markers of susceptibility to bladder cancer.

This bladder GWAS has led to the discovery of three novel regions in the genome associated with...

phs000346.v1.p1 | EGA
Sort   by:  
 Page size