Sort   by:  
 Page size 
TranscriptomicsHAVCR/KIM-1 activates the IL-6/STAT-3 Pathway in ccRCC and Determines Tumor Progression and Patient Outcome
Renal cell carcinoma (RCC), the third most prevalent urological cancer, claims more than 100,000 lives/year worldwide. The clear cell (ccRCC) is the most common and aggressive subtype of renal cancer. Commonly asymptomatic, more than 30% of ccRCCs are diagnosed when they are already metastatic resul...
ORGANISM(S): Homo sapiens 
2020-09-27 | E-MTAB-2071 | biostudies-arrayexpress
TranscriptomicsGene expression of murine B cells activated via TLR4 or TLR4 + CD40: Group1 naM-CM-/ve B cells, Group2 LPS activated B cells 24h, Group3 LPS + anti-CD40 activated B cells 24h, Group4 LPS activated B cells 72h, and Group5 LPS + anti-CD40 activated B cells 72h.
Murine B cells can be activated via the surface receptors TLR4 and CD40. For a global assessment of differences in gene expression between these two different modes of B cell activation a genome wide transcriptome analysis was performed. In order to dissect different gene expression profiles of B ce...
ORGANISM(S): Mus musculus 
2014-02-24 | E-GEOD-35998 | biostudies-arrayexpress
TranscriptomicsHIV-specific B cells are enriched within abnormal memory subsets in infected individuals
Recently, several neutralizing anti-HIV antibodies have been isolated from memory B cells of HIV-infected individuals. However, despite extensive evidence of B-cell dysfunction in HIV disease, little is known about the cells from which these rare HIV-specific antibodies originate. Accordingly, HIV e...
ORGANISM(S): Homo sapiens 
2014-06-24 | E-GEOD-56499 | biostudies-arrayexpress
MetabolomicsMetabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide
Trypanosoma brucei is the causative agent of human African trypanosomiasis, which is responsible for thousands of deaths every year. Current therapies are limited and there is an urgent need to develop new drugs. The anti-trypanosomal compound, 3-(oxazolo[4,5-b]pyridine-2-yl)anilide (OXPA), was init...
2017-10-09 | MTBLS360 | MetaboLights
TranscriptomicsCopy number abnormality, MYC activity and the genetic fingerprint of normal B-cells and the microRNA profile of DLBCL-77
A better understanding of the pathogenesis of diffuse large B-cell lymphoma (DLBCL) has clarified its relationship to normal B-cells, pointed to distinct mechanisms of cell transformation, and facilitated the design of novel treatments. However, these data derive from mRNA genes studies, whereas ge...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-15177 | biostudies-arrayexpress
TranscriptomicsCopy number abnormality, MYC activity and the genetic fingerprint of normal B-cells and the microRNA profile of DLBCL-21
A better understanding of the pathogenesis of diffuse large B-cell lymphoma (DLBCL) has clarified its relationship to normal B-cells, pointed to distinct mechanisms of cell transformation, and facilitated the design of novel treatments. However, these data derive from mRNA genes studies, whereas gen...
ORGANISM(S): Homo sapiens 
2009-03-12 | E-GEOD-15142 | biostudies-arrayexpress
UnknownEffects of the SGLT2 inhibitor canagliflozin on plasma biomarkers TNFR-1, TNFR-2 and KIM-1 in the CANVAS trial.
Not available
S-EPMC8423682 | biostudies-literature
GenomicsRetrotransposon-based profiling of mammalian epigenomes: DNA methylation of IAP LTRs in embryonic stem, somatic and cancer cells
In this study, we analyzed the DNA methylation levels of 4799 IAP LTRs in three murine cell types: AB2.2 ES cells, somatic cells and a neuroblastoma cell line Neuro2A. According to the results, half of the IAP LTR retrotransposons show constant methylation patterns between the three cell types where...
ORGANISM(S): Mus musculus 
2015-06-15 | E-GEOD-60007 | biostudies-arrayexpress
UnknownComplete chloroplast genome of Asarum chungbuensis (C.S. Yook & J.G. Kim) B.U. Oh 2005 (Aristolochiaceae), a Korean endemic species.
Not available
S-EPMC11305027 | biostudies-literature
TranscriptomicsmicroRNA profile of DLBCL
This SuperSeries is composed of the following subset Series: GSE15142: Copy number abnormality, MYC activity and the genetic fingerprint of normal B-cells and the microRNA profile of DLBCL-21 GSE15177: Copy number abnormality, MYC activity and the genetic fingerprint of normal B-cells and the microR...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-15225 | biostudies-arrayexpress
Sort   by:  
 Page size