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UnknownGenome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland Ch...
S-EPMC4169232 | biostudies-literature
ProteomicsProteomic analysis reveals distinct metabolic differences between GM-CSF and M-CSF grown macrophages derived from murine bone marrow cells
Macrophages are crucial in controlling infectious agents and tissue homeostasis. Macrophages require a wide range of functional capabilities in order to fulfill distinct roles in our body, one being rapid and robust immune responses. To gain insight into macrophage plasticity and the key regulatory ...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-04 | PXD002582 | Pride
Macrophage Phosphoproteins Tmt Protein identification Immunology Mass spectrometry 
UnknownThe complete chloroplast genome of the Korean endemic plant <i>Sorbaria sorbifolia</i> var. <i>glandulifolia</i> J.-H. Song & S.-P. Hong (Rosaceae) and phylogenetic analysis.
Sorbaria sorbifolia var. glandulifolia, endemic to Korea, is distinguished by glandular trichomes on the abaxial leaflet surface. In this study, we present its first complete chloroplast genome (159,476 bp) with a typical quadripartite structure comprising 112 unique genes, including 7...
S-EPMC12599368 | biostudies-literature
UnknownThe Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells.
Upregulated ERK1/2 activity is correlated with androgen receptor (AR) downregulation in certain prostate cancer (PCa) that exhibits androgen deprivation-induced neuroendocrine differentiation, but its functional relevance requires elucidation. We found that sustained ERK1/2 activation using active R...
S-EPMC3189339 | biostudies-literature
UnknownMedical students' perceived stress and perceptions regarding clinical clerkship during the COVID-19 pandemic.

Background

It is important to ensure that both the qualitative and quantitative aspects of clinical education are maintained during the pandemic. Understanding students' views on clinical rotations and the extent of their perceived pandemic-related stress would thus be useful for designing a...
S-EPMC9621432 | biostudies-literature
UnknownSafety and anti-tumor effects of vismodegib in patients with refractory advanced gastric cancer: A single-arm, phase-II trial.
This phase-II study (ClinicalTrials.gov identifier: NCT03052478) aimed to evaluate the efficacy and safety of vismodegib, an inhibitor targeting the Hedgehog signaling pathway, in patients with refractory advanced gastric cancer. Patients with refractory advanced gastric cancer, whose disease had pr...
S-EPMC8899372 | biostudies-literature
UnknownChildhood Obesity-Related Mechanisms: MicroRNome and Transcriptome Changes in a Nested Case-Control Study.
Childhood obesity could contribute to adulthood obesity, leading to adverse health outcomes in adults. However, the mechanisms for how obesity is developed are still unclear. To determine the epigenome-wide and genome-wide expression changes related with childhood obesity, we compared microRNome and...
S-EPMC8389653 | biostudies-literature
TranscriptomicsStreptomyces coelicolor A3(2) SigR regulon
We determined the genomic locations of the SigR binding sites by chromatin immuno-precipitation of cross-linked DNA and hybridization on a tilling oligonucleotide array after 20 minutes of diamide treatment on cell cultures. Three independent biological samples were prepared separately from the wild...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2012-06-02 | E-GEOD-33593 | biostudies-arrayexpress
UnknownSkin repair and immunoregulatory effects of myeloid suppressor cells from human cord blood in atopic dermatitis.

Introduction

Previously, we achieved large-scale expansion of bone marrow-derived suppressor cells (MDSCs) derived from cluster of differentiation (CD)34+ cells cultured in human umbilical cord blood (hUCB) and demonstrated their immunomodulatory properties. In the present study, ...
S-EPMC10803405 | biostudies-literature
UnknownRaf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels.
While cellular LC3B and SQSTM1 levels serve as key autophagy markers, their regulation by different signaling pathways requires better understanding. Here, we report the mechanisms by which the Raf/MEK/ERK pathway regulates cellular LC3B and SQSTM1 levels. In different cell types, ΔRaf-1:ER- or B-Ra...
S-EPMC4164593 | biostudies-literature
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