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ProteomicsTotal and synaptosomal proteomic analysis
Autism spectrum disorders (ASD) represent neurodevelopmental disorders characterized by social deficits, repetitive behaviors, and various comorbidities, including epilepsy. ANK2, which encodes a neuronal scaffolding protein, is frequently mutated in ASD, but its in vivo functions and disease-relate...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-03-19 | MSV000091510 | MassIVE
TranscriptomicsmiR-431 promotes differentiation and regeneration of old skeletal muscle by targeting Smad4
we identified novel age-related microRNAs through comparative analysis of miRNA expression profiles in young and old myoblasts using next generation sequencing (NGS) small RNA profiles of young mouse and old mouse were generated by deep sequencing, in each four samples, using Illumina GAIIx
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-66267 | biostudies-arrayexpress
ProteomicsProteomic analysis of Adnp mutant mice
We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory additional to social and anxiety-related deficits in adults long after a marked decrea...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000090257 | MassIVE
ProteomicsProteomic analysis of gastric cancero patient-derived tissue ECM
Gastric cancer (GC) is a highly heterogeneous disease regarding histologic features, genotypes, and molecular phenotypes. Here, we investigated extracellular matrix (ECM)-centric analysis, examining its association with histologic subtypes and patient prognosis in human gastric cancer. We performed ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-12 | MSV000093859 | MassIVE
ProteomicsA systematic proteogenomic approach to deciphering of the missing proteins: the example of newly uncovered NHERF1 function associated with human reproductive disorder
We propose and demonstrate a systematic approach designed to combine stringent criteria for claims of missing protein (MP) identification with extensive annotation as critical components of the discovery and functional validation of MPs.
ORGANISM(S): Homo sapiens (Human) 
2018-01-05 | PXD004723 | Pride
Human Placental tissues Lc-ms/ms 
ProteomicsInhibition of Alternative Complement Pathway May Cause Secretion of Factor B, Enabling an Early Detection of Pancreatic Cancer
This study aims to elucidate the cellular mechanisms underlying the secretion of factor B (CFB), recognized for its dual role as an early biomarker of pancreatic ductal adenocarcinoma (PDAC) and as the initiating substrate for the alternative complement pathway (ACP), a crucial component of the inna...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD047043 | Pride
Complement factor b Proteomics Adrenomedullin Alternative pathway Pancreatic ductal adenocarcinoma Cancer biomarker Complement factor h 
ProteomicsPhospho-tyrosine proteomic analysis in Ptprd-meB+/– mice
PTPδ, encoded by PTPRD, is implicated in various neurological, psychiatric, and neurodevelopmental disorders, but the underlying mechanisms remain unclear. PTPδ trans-synaptically interacts with multiple postsynaptic adhesion molecules, which involves its extracellular alternatively spliced mini-exo...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-01 | PXD053554 | Pride
Phospho-tyrosine proteomic analysis Ptprd-meb Lc-ms/ms 
ProteomicsHuman Placenta profilling LTQ-OrbiTrap
Profilling normal human placantal proteomes using LTQ-OrbiTrap
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-10 | MSV000083950 | MassIVE
Proteomicsyagpm3_3
enrichment for specialized purple membrane proteins, cell culture #3; Goo et al., unpublished data.
ORGANISM(S): Halobacterium Nrc-1 (halobacterium) 
2006-12-31 | PAe000189 | PeptideAtlas
TranscriptomicsFunctional analysis of KAI1
We sequenced mRNA from mouse EML cell line under Kai1 knockdown or Kai1 overexpressing condition. KAI1 belongs to tetraspanin superfamily and is known as suppressor of tumor metastasis. Examination of mRNA levels in wildtype (WT) and KAI1 knockdown EML cells were generated by deep sequencing, in dup...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-56867 | biostudies-arrayexpress
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