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ProteomicsTotal and synaptosomal proteomic analysis
Autism spectrum disorders (ASD) represent neurodevelopmental disorders characterized by social deficits, repetitive behaviors, and various comorbidities, including epilepsy. ANK2, which encodes a neuronal scaffolding protein, is frequently mutated in ASD, but its in vivo functions and disease-relate...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-03-19 | MSV000091510 | MassIVE
UnknownNon-intrinsic ATP-binding cassette proteins ABCI19, ABCI20 and ABCI21 modulate cytokinin response at the endoplasmic reticulum in Arabidopsis thaliana.

Key message

The non-intrinsic ABC proteins ABCI20 and ABCI21 are induced by light under HY5 regulation, localize to the ER, and ameliorate cytokinin-driven growth inhibition in young Arabidopsis thaliana seedlings. The plant ATP-binding cassette (ABC) I subfamily (ABCIs) comprises heterogene...
S-EPMC7346704 | biostudies-literature
TranscriptomicsmiR-431 promotes differentiation and regeneration of old skeletal muscle by targeting Smad4
we identified novel age-related microRNAs through comparative analysis of miRNA expression profiles in young and old myoblasts using next generation sequencing (NGS) small RNA profiles of young mouse and old mouse were generated by deep sequencing, in each four samples, using Illumina GAIIx
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-66267 | biostudies-arrayexpress
ProteomicsProteomic analysis of Adnp mutant mice
We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory additional to social and anxiety-related deficits in adults long after a marked decrea...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000090257 | MassIVE
UnknownImmunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease.
Acid sphingomyelinase (ASM) has been implicated in neurodegenerative disease pathology, including Alzheimer's disease (AD). However, the specific role of plasma ASM in promoting these pathologies is poorly understood. Herein, we explore plasma ASM as a circulating factor that accelerates neuropathol...
S-EPMC10036484 | biostudies-literature
ProteomicsProteomic analysis of gastric cancero patient-derived tissue ECM
Gastric cancer (GC) is a highly heterogeneous disease regarding histologic features, genotypes, and molecular phenotypes. Here, we investigated extracellular matrix (ECM)-centric analysis, examining its association with histologic subtypes and patient prognosis in human gastric cancer. We performed ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-12 | MSV000093859 | MassIVE
MetabolomicsCeramide Promotes Lytic Reactivation of Epstein-Barr Virus in Gastric Carcinoma
Epstein-Barr virus (EBV) has a lifelong latency period after initial infection. Rarely, however, when the EBV immediate early gene BZLF1 is expressed by a specific stimulus, the virus switches to the lytic cycle to produce progeny viruses. We found that EBV infection reduced levels of various cerami...
2023-12-20 | MTBLS7649 | MetaboLights
UnknownTracing of the fecal microbiota of commercial pigs at five growth stages from birth to shipment.
The intestinal microbiota affect various physiological traits of host animals such as brain development, obesity, age, and the immune system. In the swine industry, understanding the relationship between intestinal microbiota and growth stage is essential because growth stage is directly related to ...
S-EPMC5902624 | biostudies-literature
ProteomicsA systematic proteogenomic approach to deciphering of the missing proteins: the example of newly uncovered NHERF1 function associated with human reproductive disorder
We propose and demonstrate a systematic approach designed to combine stringent criteria for claims of missing protein (MP) identification with extensive annotation as critical components of the discovery and functional validation of MPs.
ORGANISM(S): Homo sapiens (Human) 
2018-01-05 | PXD004723 | Pride
Human Placental tissues Lc-ms/ms 
MetabolomicsEffects of coronatine elicitation on growth and metabolic profiles of Lemna paucicostata culture
In this study, the effects of coronatine treatment on the growth, comprehensive metabolic profiles, and productivity of bioactive compounds, including phenolics and phytosterols, in whole plant cultures of Lemna paucicostata were investigated using gas chromatography-mass spectrometry (GC-MS) couple...
2018-09-11 | MTBLS526 | MetaboLights
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