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ProteomicsProteomic Analysis of Extracellular Vesicles Derived from Human Pluripotent Stem Cells
Extracellular vesicles (EVs) and secretory factors are key to intercellular communication, yet their molecular dynamics in human pluripotent stem cells (hPSCs) are not well understood. We identified a key EV surface protein that regulates hPSC stemness, enhances growth, and promotes EV endocytosis. ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD056373 | Pride
Extracellular vesicles Human pluripotent stem cells 
ProteomicsFormaldehyde-crosslinking enables comprehensive profiling of in vivo RNA-interactome in UV-impermeable samples
Development of UV-crosslinking based RNA-interactome capture protocol have expanded the repertoire of RBPs. Apparent limitations of UV-crosslinking, however, have made the RBP profiling to be incomplete and inapplicable to many of the biological samples in physiological contexts. Here we developed f...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2020-11-25 | PXD010046 | Pride
Rbp formaldehyde 
UnknownActive photonic wireless power transfer into live tissues.
Not available
S-EPMC7382277 | biostudies-literature
ProteomicsDevelopment of an in vitro screening system for synthetic signal peptide in mammalian cell-based protein production.
Optimizing appropriate signal peptides in mammalian cell-based protein production is crucial given that most recombinant proteins produced in mammalian cells are thought to be secreted proteins. Until now, most studies on signal peptide in mammalian cells have replaced native signal peptides with we...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2022-05-24 | PXD033441 | Pride
N-terminal sequencing using lc-ms/ms Site-specific integration system Fc-fusion protein production Signal peptide Mammalian cells Screening system 
MetabolomicsThe Green Tea Modulates Large Intestinal Microbiome and Exo/Endogenous Metabolome altered through Chronic UVB-exposure (Endogenous assays)
The attenuating effects of green tea supplements (GTS) against the ultraviolet (UV) radiation induced skin damages are distinguished. However, the concomitant effects of GTS on the large intestinal microbiomes and associated metabolomes are largely unclear. Herein, we performed an integrated microbi...
2018-09-14 | MTBLS527 | MetaboLights
ProteomicsAn integrative proteomic approach during Alzheimer’s disease progression in Tau PS19 mice
Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease associated with cognitive, functional, and behavioral impairments characterized by the progressive accumulation of extracellular amyloid-beta plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau protei...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD066515 | Pride
GenomicsAKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage.
Purpose: In this study, we show that DNA damage-activated AKT phosphorylates threonine 45 of core histone H3 (H3-T45) Result: By genome-wide chromatin immunoprecipitation sequencing (ChIP-seq) analysis, H3-T45 phosphorylation was distributed throughout DNA damage-responsive gene loci, particularly i...
ORGANISM(S): Homo sapiens 
2015-04-09 | E-GEOD-67699 | biostudies-arrayexpress
ProteomicsPGRC Cancer Proteome Study of Gastric Tissue
The goal of the project is to analyze different layers of proteome information including protein abundance and post-translational modifications of PGRC gastric tissue samples. Three pairs of human gastric cancer and adjacent normal tissues were extensively characterized by serial enrichments of phos...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080818 | MassIVE
GenomicsThese are from Korean HCC samples with exome sequencing
Hepatic resection is the most curative treatment option for early-stage hepatocellular carcinoma, but is associated with a high recurrence rate, which exceeds 50% at 5 years after surgery. Understanding the genetic basis of hepatocellular carcinoma at surgically curable stages may enable the identif...
EGAS00001000604 | EGA
ProteomicsDrug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer towards androgen-independence
In prostate cancer, androgen receptor (AR)-targeting agents are very effective in various stages of the disease. However, therapy resistance inevitably occurs and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multi-omics analyses on tissues isol...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032041 | Pride
Foxa1 Prostate cancer Androgen receptor(ar) Enzalutamide Lc-msms Arntl 
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