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GenomicsGenome-wide location analysis of Foxa1 in adult liver
We determine by genome-wide location analysis (ChIP-Seq) that Foxa1 occupies 5,682 binding sites in the adult murine liver. Although Foxa1 and its closest paralog Foxa2 (GEO accessions: GSE25836 and GSE26729) share a large fraction of binding sites in the liver, each protein also occupies distinct r...
ORGANISM(S): Mus musculus 
2012-06-21 | E-GEOD-33666 | biostudies-arrayexpress
TranscriptomicsCooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program [array]
Previous studies have shown that FOXA1 defines prostatic AR binding events, the underlying mechanisms of which, however, are incompletely understood. To test whether ectopic AR and FOXA1 can activate AR target genes, we performed adenoviral of LacZ, AR, FOXA1 or AR+FOXA1 proteins in DU145 cells, fo...
ORGANISM(S): Homo sapiens 
2014-06-02 | E-GEOD-54991 | biostudies-arrayexpress
GenomicsFoxA1 inhibits androgen receptor expression and suppresses prostate cancer metastasis [DU145, ChIP-seq]
FoxA1 has been shown critical for prostate development and prostate-specific gene expression regulation. In addition to its well-established role as an AR pioneering factor,several studies have recently revealed significant AR binding events in prostate cancer cells with FoxA1 knockdown. Furthermore...
ORGANISM(S): Homo sapiens 
2014-06-02 | E-GEOD-47987 | biostudies-arrayexpress
TranscriptomicsAndrogen receptor-independent function of FoxA1 in prostate cancer metastasis
FoxA1 has been shown critical for prostate development and prostate-specific gene expression regulation. In addition to its well-established role as an AR pioneering factor,several studies have recently revealed significant AR binding events in prostate cancer cells with FoxA1 knockdown. Furthermore...
ORGANISM(S): Homo sapiens 
2013-04-05 | E-GEOD-37314 | biostudies-arrayexpress
TranscriptomicsFOXA1 actively represses the molecular phenotype of basal breast cancers.
Breast cancer is a heterogeneous disease comprised of at least five major subtypes. Luminal subtype tumors confer a more favourable patient prognosis, which is in part, attributed to the Estrogen Receptor-alpha (ER) positivity and anti-hormone responsiveness of these tumors. Expression of the forkhe...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-31003 | biostudies-arrayexpress
GenomicsDual Role of FoxA1 in Androgen Receptor Binding to Chromatin, Androgen Signaling and Prostate Cancer [ChIP_seq, DHS_seq]
We report the dual role of FoxA1 in androgen receptor recruitment to the chromatin of androgen responsive prostate cancer cell line LNCaP-1F5 using ChIP-sequencing. Depletion of FoxA1 reprograms both androgen and glucocorticoid receptor recruitment and subsequent gene expression. The ChIP-seq has be...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-30623 | biostudies-arrayexpress
GenomicsFOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function
FOXA1 is a FKHD family protein that translates epigenetic signatures at target enhancers to lineage-specific transcription and differentiation. Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of this epigenetic signat...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-73363 | biostudies-arrayexpress
ProteomicsFOXA1 directs H3K4 monomethylation at enhancers via recruitment of the methyltransferase MLL3
FOXA1 is a pioneer factor that is important in hormone dependent cancer cells to stabilise nuclear receptors, such as estrogen receptor (ER) to chromatin. FOXA1 binds to enhancers regions that are enriched in H3K4mono- and dimethylation (H3K4me1, H3K4me2) histone marks and evidence suggests that the...
ORGANISM(S): Homo sapiens (Human) 
2016-12-12 | PXD005253 | Pride
Foxa1 H3k4 Mll3 Human Lcmsms 
GenomicsFoxA1 binding in asynchronous and mitotic HUH7 cells
During mitosis, RNA polymerase and most transcription factors are excluded from the chromosomes and transcription ceases. The transcriptional re-activation of the genome, following mitosis, requires the re-setting of cell-type specific programs that were initially established during development. H...
ORGANISM(S): Homo sapiens 
2013-03-31 | E-GEOD-39241 | biostudies-arrayexpress
GenomicsFoxA1 inhibits androgen receptor expression and suppresses prostate cancer metastasis [LNCaP, ChIP-seq]
FoxA1 has been shown critical for prostate development and prostate-specific gene expression regulation. In addition to its well-established role as an AR pioneering factor,several studies have recently revealed significant AR binding events in prostate cancer cells with FoxA1 knockdown. Furthermore...
ORGANISM(S): Homo sapiens 
2014-06-02 | E-GEOD-37345 | biostudies-arrayexpress
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