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GenomicsEnhancer-associated H3K4 mono-methylation by Drosophila Trithorax-related, the Drosophila homolog of Mll3/Mll4
Mono-methylation of histone H3 on lysine 4 (H3K4me1) and acetylation of histone H3 on lysine 27 (H3K27ac) are histone modifications that are highly enriched over the body of actively transcribed genes and enhancers. Although in yeast all H3K4 methylation patterns including H3K4me1 are implemented by...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-41440 | biostudies-arrayexpress
ProteomicsFOXA1 directs H3K4 monomethylation at enhancers via recruitment of the methyltransferase MLL3
FOXA1 is a pioneer factor that is important in hormone dependent cancer cells to stabilise nuclear receptors, such as estrogen receptor (ER) to chromatin. FOXA1 binds to enhancers regions that are enriched in H3K4mono- and dimethylation (H3K4me1, H3K4me2) histone marks and evidence suggests that the...
ORGANISM(S): Homo sapiens (Human) 
2016-12-12 | PXD005253 | Pride
Foxa1 H3k4 Mll3 Human Lcmsms 
GenomicsThe MLL3/MLL4 branch of the COMPASS family regulates H3K4 monomethylation at enhancers
Histone H3 lysine 4 (H3K4) can be mono-, di-, and trimethylated by members of the COMPASS (COMplex of Proteins ASsociated with Set1) family from yeast to human and these modifications can be found at distinct regions of the genome. Monomethylation of histone H3K4 (H3K4me1) is relatively more enriche...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-51176 | biostudies-arrayexpress
GenomicsEffect of Mll3 deletion in MCF7 cells
Effect of Mll3 deletion in MCF7 cells
PRJNA719656 | ENA
GenomicsChIP-seq of MLL3 Delta mice liver and wild-type littermate controls
We investigated the in vivo role of MLL3-dependent methylation of histone 3 lysine 4 at zeitgeber time 18, by performing H3K4me1 and H3K4me3 ChIP-seq in mouse liver, from MLL3 Delta mice and littermate wild-type controls.
ORGANISM(S): Mus musculus 
2022-05-01 | E-MTAB-11203 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Mll3 knockdown p53-/- HSPC vs. control p53-/- HSPC
Recurring deletions of chromosome 7 and 7q [-7/del(7q)] occur in myelodysplastic syndromes and acute myeloid leukemia (AML) and are associated with poor prognosis. However, the identity of specific tumor suppressors on 7q remains elusive. Using RNAi and CRISPR/Cas9 approaches, we show that a ~50% r...
ORGANISM(S): Mus musculus 
2014-03-19 | E-GEOD-54313 | biostudies-arrayexpress
GenomicsMLL3 is a de novo Cause of Endocrine Therapy Resistance
MLL3 is a de novo Cause of Endocrine Therapy Resistance
PRJNA685435 | ENA
GenomicsMLL3 and Calcineurin project in hypertrophic hearts
Identification of MLL3 and Calcineurin genomic targets in hypertrophic hearts
PRJEB50435 | ENA
GenomicsMLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity [ChIP-seq]
MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity [ChIP-seq]
PRJNA672157 | ENA
GenomicsMLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity [RNA-seq]
MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity [RNA-seq]
PRJNA672784 | ENA
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