Sort   by:  
 Page size 
MetabolomicsDisruption of Methionine Metabolism Drives Erythroid Cell Fate Reprogramming by Remodeling the H3K4me3 Landscape

Methionine cycle plays critical roles in cell fate determination by shaping epigenetic landscape, yet its function in human erythropoiesis remains undefined. Here, we show that disruption of methionine metabolism by compromising key enzyme adenosylhomocysteinase (AHCY) reshapes H3K4me3 landscape,...

2026-06-10 | MTBLS10469 | MetaboLights
MetabolomicsHistone H3K4me3 Demethylase RBP2 Transcriptionally Activates PPARγ to Drive Lipid Metabolic Reprogramming in Gastric Carcinoma

This work investigates epigenetic driven lipid metabolic reprogramming in gastric carcinoma. We characterize that histone H3K4me3 demethylase RBP2 transcriptionally activates PPARgama by binding to its promoter region,thereby promoting lipogenic gene expression and intracellular lipid accumulatio...

2026-08-14 | MTBLS15324 | MetaboLights
TranscriptomicsMembers of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
The plasticity of ageing suggests that longevity may be controlled epigenetically by specific alterations in chromatin state. The link between chromatin and ageing has mostly focused on histone deacetylation by the Sir2 family1, 2, but less is known about the role of other histone modifications in l...
ORGANISM(S): Caenorhabditis elegans 
2011-07-08 | E-GEOD-30505 | biostudies-arrayexpress
GenomicsKDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation [ChIP-Seq]
Pluripotency of embryonic stem (ES) cells is controlled in part by chromatin-modifying factors that regulate histone H3 lysine 4 (H3K4) methylation. However, it remains unclear how H3K4 demethylation contributes to ES cell function. Here, we show that KDM5B, which demethylates lysine 4 of histone H3...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-53087 | biostudies-arrayexpress
TranscriptomicsKDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation [RNA-Seq]
Pluripotency of embryonic stem (ES) cells is controlled in part by chromatin-modifying factors that regulate histone H3 lysine 4 (H3K4) methylation. However, it remains unclear how H3K4 demethylation contributes to ES cell function. Here, we show that KDM5B, which demethylates lysine 4 of histone H3...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-53090 | biostudies-arrayexpress
GenomicsMammalian Dpy-30 regulates genomic H3K4 methylation and is essential for ES cell fate specification
H3K4 methylation is associated with active genes and, along with H3K27 methylation, is part of a bivalent chromatin mark that typifies poised developmental genes in ESCs. However, its functional roles in ESC maintenance and differentiation are not established. Here we show that mammalian Dpy-30, a c...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-26136 | biostudies-arrayexpress
ProteomicsBRWD3 targets KDM5/Lid for degradation to maintain H3K4 methylation levels
Histone modifications are critical for regulating chromatin structure and gene expression. Dysregulation of histone modification levels may contribute to disease development and cancer. Therefore, understanding histone modifications is essential for development and disease. The chromatin-binding pro...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-09-19 | PXD039706 | Pride
H3k4 Histone Degradation E3 ubiquitin ligase Brwd3 
GenomicsCo-dependency of H2B monoubiquitination and nucleosome re-assembly on Chd1
Monoubiquitination of histone H2B on lysine 123  (H2BK123ub) is a transient histone modification considered to be essential for establishing H3K4 and H3K79 trimethylation by Set1/COMPASS and Dot1, respectively.  Many of the factors such as Rad6/Bre1, the Paf1 complex, and the Bur1/Bur2 complex were ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-05-01 | E-GEOD-36334 | biostudies-arrayexpress
GenomicsDynamic loss of H2B ubiquitylation without corresponding changes in H3K4 tri-methylation during myogenic differentiation
Ubiquitylation of H2B on lysine 120 (H2Bub) is associated with active transcriptional elongation. H2Bub has been implicated in histone cross-talk and is generally regarded to be a prerequisite for H3K4 and H3K79 tri-methylation in both yeast and mammalian cells. We performed a genome-wide analysis o...
ORGANISM(S): Mus musculus 
2012-03-06 | E-GEOD-34960 | biostudies-arrayexpress
GenomicsThe MLL3/MLL4 branch of the COMPASS family regulates H3K4 monomethylation at enhancers
Histone H3 lysine 4 (H3K4) can be mono-, di-, and trimethylated by members of the COMPASS (COMplex of Proteins ASsociated with Set1) family from yeast to human and these modifications can be found at distinct regions of the genome. Monomethylation of histone H3K4 (H3K4me1) is relatively more enriche...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-51176 | biostudies-arrayexpress
Sort   by:  
 Page size