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ProteomicsBRWD3 targets KDM5/Lid for degradation to maintain H3K4 methylation levels
Histone modifications are critical for regulating chromatin structure and gene expression. Dysregulation of histone modification levels may contribute to disease development and cancer. Therefore, understanding histone modifications is essential for development and disease. The chromatin-binding pro...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-09-19 | PXD039706 | Pride
H3k4 Histone Degradation E3 ubiquitin ligase Brwd3 
GenomicsBRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels
BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels
PRJNA991928 | ENA
GenomicsBRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels
Histone modifications are critical for regulating chromatin structure and gene expression. Dysregulation of histone modifications likely contributes to disease states and cancer. Depletion of the chromatin-binding protein BRWD3, a known substrate-specificity factor of the Cul4-DDB1 E3 ubiquitin liga...
ORGANISM(S): Drosophila melanogaster 
2024-09-30 | GSE236629 | GEO
UnknownBRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels.
Not available
S-EPMC10081218 | biostudies-literature
UnknownBRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels.
Not available
S-EPMC10523488 | biostudies-literature
UnknownVariants in BRWD3 associated with X-linked partial epilepsy without intellectual disability.
Not available
S-EPMC9873514 | biostudies-literature
UnknownMutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly.
Not available
S-EPMC1950797 | biostudies-literature
GenomicsDDB1 Binds Histone Reader BRWD3 to Activate the Transcriptional Cascade in Adipogenesis and Promote Onset of Obesity (RNA-Seq)
DDB1 Binds Histone Reader BRWD3 to Activate the Transcriptional Cascade in Adipogenesis and Promote Onset of Obesity (RNA-Seq)
PRJNA664203 | ENA
GenomicsDDB1 Binds Histone Reader BRWD3 to Activate the Transcriptional Cascade in Adipogenesis and Promote Onset of Obesity (ChIP-Seq)
DDB1 Binds Histone Reader BRWD3 to Activate the Transcriptional Cascade in Adipogenesis and Promote Onset of Obesity (ChIP-Seq)
PRJNA664202 | ENA
ProteomicsdBRWD3 manipulates chromatin signature by ubiquitination to regulate ORC
Ubiquitination and epigenetic modification both play essential roles in regulating cell fates and development, but little is known how two pathways crosstalk. A known chromatin-binding protein BRWD3, Bromodomain repeats and WD40 repeats domain contain protein 3, has been shown involved both in ubiqu...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-10-24 | PXD039708 | Pride
Histone Wd40 Degradation E3 ubiquitin ligase Dbrwd3 Orc 
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