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TranscriptomicsTranscriptome analyses of dBRWD3 mutant, and dBRWD3, yem double mutant brain
We report the high-throughput profiling of brain RNA from three Drosophila stains: dBRWD3PX2/+, dBRWD3PX2/PX2 and dBRWD3PX2/PX2, yemGS21861/GS21861. By obtaining over 50 million reads of sequence, WE compared the transcriptomic differences among the brains from these three stains. We found that the ...
ORGANISM(S): Drosophila melanogaster 
2015-01-19 | E-GEOD-64009 | biostudies-arrayexpress
TranscriptomicsTranscriptome analyses of dBRWD3 mutant, and dBRWD3, yem double mutant brain
We report the high-throughput profiling of brain RNA from three Drosophila stains: dBRWD3PX2/+, dBRWD3PX2/PX2 and dBRWD3PX2/PX2, yemGS21861/GS21861. By obtaining over 50 million reads of sequence, WE compared the transcriptomic differences among the brains from these three stains. We found that the ...
ORGANISM(S): Drosophila melanogaster 
2015-01-19 | GSE64009 | GEO
ProteomicsdBRWD3 manipulates chromatin signature by ubiquitination to regulate ORC
Ubiquitination and epigenetic modification both play essential roles in regulating cell fates and development, but little is known how two pathways crosstalk. A known chromatin-binding protein BRWD3, Bromodomain repeats and WD40 repeats domain contain protein 3, has been shown involved both in ubiqu...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-10-24 | PXD039708 | Pride
Histone Wd40 Degradation E3 ubiquitin ligase Dbrwd3 Orc 
UnknowndBRWD3 Regulates Tissue Overgrowth and Ectopic Gene Expression Caused by Polycomb Group Mutations.
Not available
S-EPMC5010193 | biostudies-literature
GenomicsDrosophila melanogaster
Transcriptome analyses of dBRWD3 mutant, and dBRWD3, yem double mutant brain
PRJNA269754 | ENA
UnknownIntellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3.
Not available
S-EPMC4388619 | biostudies-literature
TranscriptomicsA cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation
Histone H3 Lys4 (H3K4) methylation is a chromatin feature enriched at gene cis-regulatory sequences such as promoters and enhancers. Here we identify an evolutionarily conserved factor, BRWD2/PHIP, which colocalizes with histone H3K4 methylation genome-wide in human cells, mouse embryonic stem cells...
ORGANISM(S): Drosophila melanogaster Homo sapiens Mus musculus 
2017-11-02 | GSE101646 | GEO
TranscriptomicsmRNA cap methylation in pluripotency and differentiation
The mRNA cap recruits factors essential for transcript processing and translation initiation. We report that regulated mRNA cap methylation is a feature of embryonic stem cell (ESC) differentiation. Expression of the mRNA cap methyltransferase activating subunit, RAM, is elevated in ESCs resulting i...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-81849 | biostudies-arrayexpress
TranscriptomicsMetabolic switching of the PII protein GlnK in Streptomyces coelicolor
GlnK is an important nitrogen sensor protein in Streptomyces coelicolor. Deletion of glnK results in a medium-dependent failure of aerial mycelium and spore formation and loss of antibiotic production. Thus, GlnK is not only a regulator of nitrogen metabolism but also of morphological differentiatio...
ORGANISM(S): Streptomyces coelicolor 
2011-12-31 | E-GEOD-30570 | biostudies-arrayexpress
GenomicsA cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation
A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation
PRJNA395067 | ENA
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