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UnknownIL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle.
Altered energy balance and insulin resistance are important characteristics of aging. Skeletal muscle is a major site of glucose disposal, and the role of aging-associated inflammation in skeletal muscle insulin resistance remains unclear. To investigate, we examined glucose metabolism in 18-mo-old ...
S-EPMC5240661 | biostudies-literature
UnknownUse of heat stress responsive gene expression levels for early selection of heat tolerant cabbage (Brassica oleracea L.).
Cabbage is a relatively robust vegetable at low temperatures. However, at high temperatures, cabbage has disadvantages, such as reduced disease tolerance and lower yields. Thus, selection of heat-tolerant cabbage is an important goal in cabbage breeding. Easier or faster selection of superior variet...
S-EPMC3709761 | biostudies-literature
UnknownDevelopmental Roles of FUSE Binding Protein 1 (Fubp1) in Tooth Morphogenesis.
FUSE binding protein 1 (Fubp1), a regulator of the c-Myc transcription factor and a DNA/RNA-binding protein, plays important roles in the regulation of gene transcription and cellular physiology. In this study, to reveal the precise developmental function of Fubp1, we examined the deta...
S-EPMC7663687 | biostudies-literature
UnknownTEAD2 as a novel prognostic factor for hepatocellular carcinoma.
TEA Domain Transcription Factors (TEADs) are important in development and serve essential roles in tumorigenesis; however, the role of TEAD2 expression in hepatocellular carcinoma (HCC) has not been widely examined. The present study was conducted to investigate the expression status of TEAD2 in HCC...
S-EPMC7160555 | biostudies-literature
UnknownRNA-sequencing profiling analysis of pericyte-derived extracellular vesicle-mimetic nanovesicles-regulated genes in primary cultured fibroblasts from normal and Peyronie's disease penile tunica albuginea.

Background

Peyronie's disease (PD) is a severe fibrotic disease of the tunica albuginea that causes penis curvature and leads to penile pain, deformity, and erectile dysfunction. The role of pericytes in the pathogenesis of fibrosis has recently been determined. Extracellular vesicle (EV)-mi...
S-EPMC8344132 | biostudies-literature
UnknownVasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice.
Neovascularization of the erectile tissue emerges as a beneficial curative approach to treat erectile dysfunction (ED). Here we for the first time report the unexpected role of vasohibin-1 (VASH1), mainly known as an anti-angiogenic factor, in restoring erectile function in diabetic mice. A diabetic...
S-EPMC7807034 | biostudies-literature
GenomicsWhole-genome landscape of histone H2AX and γ-H2AX along with related factors in activated cells
Phosphorylation of the histone variant H2AX forms γ-H2AX, which serves as a marker of DNA repair response. Here we provide ChIP-seq-based maps of histone H2AX, γ-H2AX, H2AZ, INO80, SRCAP, and RNA polymerase II in activated T cells. Matched data for H2AX and γ-H2AX in resting T cells and Jurkat ca...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-44309 | biostudies-arrayexpress
UnknownEmergence of HPAI H5N6 Clade 2.3.4.4b in Wild Birds: A Case Study From South Korea, 2023.
The emergence and evolution of avian influenza A viruses (AIVs) pose significant challenges to both public health and animal husbandry worldwide. Here, we characterized a novel reassortant highly pathogenic avian influenza virus (HPAIV), clade 2.3.4.4b H5N6, that was isolated from a mandarin duck in...
S-EPMC12020246 | biostudies-literature
UnknownViscous Cervical Environment-on-a-Chip for Selecting High-Quality Sperm from Human Semen.
When ejaculated sperm travels through the vagina to the uterus, mucus secreted by the cervical canal generally filters out sperm having low motility and poor morphology. To investigate this selection principle in vivo, we developed a microfluidic sperm-sorting chip with a viscous medium (polyvinylpy...
S-EPMC8533482 | biostudies-literature
UnknownTranscriptional Network Analysis Reveals Drought Resistance Mechanisms of AP2/ERF Transgenic Rice.
This study was designed to investigate at the molecular level how a transgenic version of rice "Nipponbare" obtained a drought-resistant phenotype. Using multi-omics sequencing data, we compared wild-type rice (WT) and a transgenic version (erf71) that had obtained a drought-resistant phenoty...
S-EPMC5471331 | biostudies-literature
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