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ProteomicsMolecular mechanism of β-arrestin 2 interaction with phosphorylated intracellular loop 3 of dopamine receptor D2
G protein-coupled receptors (GPCRs) are essential signaling molecules involved in various physiological processes, with β-arrestins playing crucial roles in receptor desensitization, internalization, and G protein-independent signaling. Although the interaction between the phosphorylated C-terminal ...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-09 | PXD056442 | Pride
Arrestin Dopamine receptor d2 Phosphorylated intracellular loop 3 Hydrogen/deuterium exchange mass spectrometry (hdx-ms) 
ProteomicsMolecular mechanism of β-arrestin-2 pre-activation by phosphatidylinositol 4,5-bisphosphate
Arrestins are a protein family that regulate G protein-coupled receptor (GPCR) signaling, with four distinct members in mammals (arrestin 1–4). Phosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin, resulting in C-terminus release. This induces further allosteric co...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-07-15 | PXD049391 | Pride
Arrestin Hydrogen/deuterium exchange mass spectrometry (hdx-ms) 5-bisphosphate Phosphatidylinositol 4 
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