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ProteomicsExploring GPCR-arrestin interfaces with genetically encoded crosslinkers
-arrestins (arr1 and arr2) are ubiquitous regulators of G protein-coupled receptor (GPCR) signalling. Available data suggest that -arrestins dock to different receptors in different ways. However, the structural characterization of arrestin-GPCR complexes is challenging and alternative approaches to...
ORGANISM(S): Homo sapiens (Human) 
2020-09-21 | PXD020418 | Pride
-arrestins / genetically encoded crosslinkers / g protein-coupled receptor / gpcr-arrestin complexes / live cells 
ModelsCoggins2014 - CXCL12 dependent recruitment of beta arrestin
Nathaniel L. Coggins, Danielle Trakimas, S. Laura Chang, Anna Ehrlich, Paramita Ray, Kathryn E. Luker, Jennifer J. Linderman & Gary D. Luker. CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7. PLoS ONE 9, 6 (2014). Chemokine CXCL12 promotes growth a...
2024-09-02 | BIOMD0000000599 | BioModels
Proteomicsα-arrestin-dependent endocytosis after cycloheximide treatment
To identify new plasma membrane (PM) proteins that require α-arrestins for endocytosis, we performed an iTRAQ-based quantitative proteomic screening. We analysed and compared the PM proteome for each arrestin knockout (art∆) strain to a WT strain after a 90 min cycloheximide (CHX) treatment. CHX is ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-09-25 | PXD014695 | Pride
Endocytosis Arrestin Plasma membrane Cycloheximide 
ProteomicsMolecular mechanism of β-arrestin 2 interaction with phosphorylated intracellular loop 3 of dopamine receptor D2
G protein-coupled receptors (GPCRs) are essential signaling molecules involved in various physiological processes, with β-arrestins playing crucial roles in receptor desensitization, internalization, and G protein-independent signaling. Although the interaction between the phosphorylated C-terminal ...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-09 | PXD056442 | Pride
Arrestin Dopamine receptor d2 Phosphorylated intracellular loop 3 Hydrogen/deuterium exchange mass spectrometry (hdx-ms) 
GenomicsLung transcriptomes of wild type, β-arrestin 1 -/-, and β-arrestin 2 -/- mice exposed to normoxia or chronic hypoxia
Lung transcriptomes of wild type, β-arrestin 1 -/-, and β-arrestin 2 -/- mice exposed to normoxia or chronic hypoxia
PRJNA432928 | ENA
TranscriptomicsNicotinic acetylcholine receptors and EGF induce c-Kit ligand/Stem Cell Factor (SCF) in a M-NM-2-arrestin-1 and E2F1 dependent manner in NSCLC
Lung cancer remains the leading cause of cancer-related deaths worldwide. M-NM-2-arrestin-1 (ARRB1), a scaffolding protein involved in the termination or desensitization of signals arising from activated G-protein-coupled receptors (GPCRs) has been shown to play a role in invasion and proliferation ...
ORGANISM(S): Homo sapiens 
2013-11-10 | E-GEOD-44617 | biostudies-arrayexpress
ProteomicsMolecular mechanism of β-arrestin-2 pre-activation by phosphatidylinositol 4,5-bisphosphate
Arrestins are a protein family that regulate G protein-coupled receptor (GPCR) signaling, with four distinct members in mammals (arrestin 1–4). Phosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin, resulting in C-terminus release. This induces further allosteric co...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-07-15 | PXD049391 | Pride
Arrestin Hydrogen/deuterium exchange mass spectrometry (hdx-ms) 5-bisphosphate Phosphatidylinositol 4 
TranscriptomicsLung transcriptomes of wild type, β-arrestin 1 -/-, and β-arrestin 2 -/- mice exposed to normoxia or chronic hypoxia
We found that β-arrestin 1 -/- mice were more sensitive to hypoxia-induced pulmonary arterial hypertension with increased right ventricle hypertrophy and higher right ventricle systolic pressure, while β-arrestin 2 -/- mice developed right ventricle hypertrophy comparable to wild type mice. Moreover...
ORGANISM(S): Mus musculus 
2018-11-19 | GSE110131 | GEO
TranscriptomicsImpact of beta-arrestin-2 deficiency on intestinal tumorigenesis in Apc-mutated mice
This SuperSeries is composed of the following subset Series: GSE24575: Beta-arrestin-2 deficiency effect on intestinal tumorigenesis in Apc-mutated mice GSE24576: Gene expression analysis of tumors from ApcD14/+ mice Refer to individual Series
ORGANISM(S): Mus musculus 
2012-01-20 | E-GEOD-24577 | biostudies-arrayexpress
Transcriptomicsbeta-arrestin-2 deficiency effect on intestinal tumorigenesis in Apc-mutated mice
Amoung their pleiotropic functions, a role was recently assigned for b-arrestin scaffold proteins in tumor growth, angiogenesis and invasion. In order to elucidate the roles of b-arrestins in tumour developement in intestinal epithelium initiated by Apc mutation, we determined the effects of b-arres...
ORGANISM(S): Mus musculus 
2012-01-20 | E-GEOD-24575 | biostudies-arrayexpress
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