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TranscriptomicsNanostring profiling for immunologically relevant genes on RNA samples isolated from E. coli stimulated human FIP2 silenced macrophages
In order to investigate the importance of FIP2 on bacterially induced gene regulation, we performed a targeted transcriptome profiling for immunologically relevant genes on RNA samples isolated from E. coli stimulated human macrophages from 7 donor treated with non-targeting and FIP2 silencing siRNA...
ORGANISM(S): Homo sapiens 
2019-03-08 | E-MTAB-6790 | biostudies-arrayexpress
TranscriptomicsToll-like receptor 7 is a primary sensor of malaria infection
Microarray profiling of amplified total splenic RNA isolated from TLR9-, TLR7-, UNC93b1- or MYD88- deficient mice or their C57BL/6 controls 24h after mock infection or infection with Plasmodium chabaudi. 4 independent replicates collected from each genotype/infection group, RNA isolated and amplifie...
ORGANISM(S): Mus musculus 
2013-09-21 | E-GEOD-41496 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of surgical liver biopsies from 13 obese (nine with type 2 diabetes) and five control subjects
Hepatic lipid accumulation is an important complication of obesity linked to risk for type 2 diabetes. To identify novel transcriptional changes in human liver which could contribute to hepatic lipid accumulation and associated insulin resistance and type 2 diabetes (DM2), we evaluated gene expressi...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-15653 | biostudies-arrayexpress
UnknownDouble-blind, randomized trial of docetaxel plus vandetanib versus docetaxel plus placebo in platinum-pretreated metastatic urothelial cancer.
Not available
S-EPMC4104290 | biostudies-literature
UnknownFecal Metabolomic Signatures in Colorectal Adenoma Patients Are Associated with Gut Microbiota and Early Events of Colorectal Cancer Pathogenesis.
Not available
S-EPMC7029137 | biostudies-literature
UnknownTP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.
Not available
S-EPMC5815403 | biostudies-literature
ProteomicsMulti-omics and Network Evaluation of Arogenate Dehydratase Knock-out Mutants in Arabidopsis thaliana
By knocking out genes encoding specific arogenate dehydrase (ADT) enzymes in Arabidopsis, variable reductions in lignin can be achieved. To understand how ADT composition affects plant phenotypes and biomolecular systems, we successfully constructed single and multiple ADT knockout (KO) mutants in A...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
MSV000081518 | MassIVE
ProteomicsDiscovery of an ApoE4-Targeted Small-Molecule SirT1 Enhancer for the Treatment of Alzheimer’s Disease
Herein we describe the discovery of an orally brain-22 permeable small-molecule, DDL-218, that enhanced SirT1 in ApoE4-expressing neuronal cells 23 and a murine AD model. DDL-218 increased the transcription factor NFYb resulting in 24 upregulation of PRMT5. Mechanistic and modeling studies show that...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD060379 | Pride
Sirtuin 1 Prmt5 Nfyb Sirt1 Sirt1 enhancer Memory Apolipoprotein e4 
TranscriptomicsGene expression in Maize root region 1 at low water potential
Previous work showed that the maize primary root adapts to low water potential (-1.6 MPa) by maintaining longitudinal expansion in the apical 3 mm (region 1), whereas in the adjacent 4 mm (region 2) longitudinal expansion reaches a maximum in well-watered roots but is progressively inhibited at low ...
ORGANISM(S): Zea mays 
2010-05-26 | E-GEOD-9341 | biostudies-arrayexpress
UnknownBidirectional relationship between olfaction and Parkinson's disease.
Not available
S-EPMC11621548 | biostudies-literature
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