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TranscriptomicsGene expression profiling study by RNA-seq in colorectal cancer
The objective of this study is to identify a prognostic signature in colorectal cancer (CRC) patients with diverse progression and heterogeneity of CRCs. We generated RNA-seq data of 54 samples (normal colon, primary CRC, and liver metastasis) from 18 CRC patients and, from the RNA-seq data, identif...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-50760 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Molecular Signature of Cholangiocarcinoma and Its Trandifferentation-Related Genes
Cholangiocarcinoma (CC) is an aggressive tumor that shows a poor survival rate even after resection. The present study aimed at identification of the genome-wide expressed genes related to CC oncogenesis and its sarcomatous transdifferentiation using DNA microarray technology. The differentially exp...
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-22633 | biostudies-arrayexpress
TranscriptomicsDNA methylation and expression profiling study for prostate cancer
Microarray-based DNA methylation and gene expression profiling was carried out using a panel of prostate cancer cell lines (LNCaP-FGC, DU-145, and PC-3) and the control normal prostate RWPE1 cell line. The identification of prostate cancer-specific methylation markers was based on the following crit...
ORGANISM(S): Homo sapiens 
2011-07-24 | E-GEOD-23388 | biostudies-arrayexpress
TranscriptomicsPredictive Gene Signatures as Strong Prognostic Indicators of the Effectiveness of BCG Immunotherapy
Full title: Predictive Gene Signatures as Strong Prognostic Indicators of the Effectiveness of Bacillus Calmetteâ??Guérin (BCG) Immunotherapy in Primary pT1 Bladder Cancers Intravesical BCG immunotherapy is effective in prevention of recurrence and progression in many cases of non-muscle invasive b...
ORGANISM(S): Homo sapiens 
2010-04-07 | E-GEOD-19423 | biostudies-arrayexpress
TranscriptomicsGene expression study for effectiveness of nicotinamide using chemically-induced mouse bladder cancer model
The objective of this study was to evaluate the efficacy of nicotinamide in a N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-induced urinary bladder cancer model in mice, and to identify through gene expression profiling the molecular signatures of cancer prevention by nicotinamide. We used 20 mice fo...
ORGANISM(S): Mus musculus 
2011-12-12 | E-GEOD-21636 | biostudies-arrayexpress
TranscriptomicsPredective Value of Prognosis-Related Gene Expression Study in Primary Bladder Cancer
This study aimed to identify the genetic signatures associated with disease prognosis in bladder cancer. We used 165 primary bladder cancer samples, 23 recurrent non-muscle invasive tumor tissues, 58 normal looking bladder mucosae surrounding cancer and 10 normal bladder mucosae for microarray analy...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-13507 | biostudies-arrayexpress
TranscriptomicsGene expression study in hepatocellular carcinoma
Gene expression data from 100 human hepatocellular carcinomas (HCC) were generated and analyzed as part of effort for validating prognostic gene expression signatures from previous studies. Using four different classification algorithms and leave-one-out cross-validation approaches, four different p...
ORGANISM(S): Homo sapiens 
2010-07-08 | E-GEOD-16757 | biostudies-arrayexpress
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