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ProteomicsSARS-CoV-2 Nsp2 recruits GIGYF2 near viral replication sites and supports viral protein production
The SARS-CoV-2 genome encodes 16 non-structural proteins (Nsps), with Nsp2 being the least conserved and least understood. In this study, we found a crucial role of Nsp2 in the SARS-CoV-2 life cycle and demonstrated its interaction with GIGYF2, which causes the relocation of GIGYF2 to near double me...
ORGANISM(S): Homo sapiens (Human) 
2025-07-26 | PXD052138 | Pride
Sars-cov-2 Gigyf2 Virus Nsp2 
UnknownNeural basis of opioid-induced respiratory depression and its rescue.
Not available
S-EPMC8201770 | biostudies-literature
ProteomicsThe dsRNA-proximal proteome during SARS-CoV-2 infection
Coronaviruses establish replication organelles to synthesize their RNAs while evading host defenses. To systematically profile the host factors and the dynamic interplay between viral and host factors during viral replication, we develop an antibody-based proximity labeling strategy targeting double...
ORGANISM(S): Homo sapiens (Human) 
2026-07-27 | PXD069353 | Pride
Replication organelle Sars-cov-2 Proximity labeling 
UnknownDivergent brainstem opioidergic pathways that coordinate breathing with pain and emotions.
Not available
S-EPMC8897232 | biostudies-literature
UnknownPresynaptic sensor and silencer of peptidergic transmission reveal neuropeptides as primary transmitters in pontine fear circuit.
Not available
S-EPMC11380597 | biostudies-literature
UnknownA central alarm system that gates multi-sensory innate threat cues to the amygdala.
Not available
S-EPMC9420642 | biostudies-literature
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