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ProteomicsTranslational repression of NMD targets by GIGYF2 and EIF4E2
Translation of messenger RNAs (mRNAs) with premature translation termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered by ribosomes terminating upstream of a splice site marked by ...
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD027479 | Pride
Nmd Eif4e2 Gigyf2 Translation 
ProteomicsInteractome of GIGYF2 and EIF4E2 with and without SMG1i treatement
Translation of messenger RNAs (mRNAs) with premature translation termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered by ribosomes terminating upstream of a splice site marked by ...
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD027487 | Pride
Nmd Smg1i Gigyf2. eif4e2 
ProteomicsSARS-CoV-2 Nsp2 recruits GIGYF2 near viral replication sites and supports viral protein production
The SARS-CoV-2 genome encodes 16 non-structural proteins (Nsps), with Nsp2 being the least conserved and least understood. In this study, we found a crucial role of Nsp2 in the SARS-CoV-2 life cycle and demonstrated its interaction with GIGYF2, which causes the relocation of GIGYF2 to near double me...
ORGANISM(S): Homo sapiens (Human) 
2025-07-26 | PXD052138 | Pride
Sars-cov-2 Gigyf2 Virus Nsp2 
GenomicsSARS-CoV-2 Nsp2 recruits GIGYF2 near viral replication sites and supports viral protein production
SARS-CoV-2 Nsp2 recruits GIGYF2 near viral replication sites and supports viral protein production
PRJNA1122521 | ENA
GenomicsSARS-CoV-2 Nsp2 recruits GIGYF2 near viral replication sites and supports viral protein production [shgigyf2_rna_seq]
SARS-CoV-2 Nsp2 recruits GIGYF2 near viral replication sites and supports viral protein production [shgigyf2_rna_seq]
PRJNA1122524 | ENA
GenomicsSARS-CoV-2 Nsp2 recruits GIGYF2 near viral replication sites and supports viral protein production [nsp2_del_rna_seq]
SARS-CoV-2 Nsp2 recruits GIGYF2 near viral replication sites and supports viral protein production [nsp2_del_rna_seq]
PRJNA1122525 | ENA
UnknownVariation in GIGYF2 is not associated with Parkinson disease.
Not available
S-EPMC2690967 | biostudies-literature
UnknownNo evidence that human GIGYF2 interacts with GRB10: implications for human disease.
Not available
S-EPMC12171015 | biostudies-literature
Unknown4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2.
Not available
S-EPMC6009589 | biostudies-literature
UnknownMeta-analyses of seven GIGYF2 polymorphisms with Parkinson's disease.
Not available
S-EPMC4179736 | biostudies-literature
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