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TranscriptomicsRNA-Seq of SMG1 inhibition via SMG1i in human foreskin fibroblast (HFF) and human umbilical vein endothelial cells (HUVEC)
UPF1 is a multi-domain RNA helicase that constantly monitors the transcriptome by non-specifically binding to mRNAs, dissociating from non-target transcripts, and initiating degradation on selected target RNAs via multiple proposed pathways such as nonsense-mediated decay (NMD). NMD is a translation...
ORGANISM(S): Homo sapiens 
2025-09-01 | E-MTAB-14755 | biostudies-arrayexpress
GenomicsRNA-Seq of SMG1 inhibition via SMG1i in human foreskin fibroblast (HFF) and human umbilical vein endothelial cells (HUVEC)
RNA-Seq of SMG1 inhibition via SMG1i in human foreskin fibroblast (HFF) and human umbilical vein endothelial cells (HUVEC)
PRJEB85059 | ENA
ProteomicsInteractome of GIGYF2 and EIF4E2 with and without SMG1i treatement
Translation of messenger RNAs (mRNAs) with premature translation termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered by ribosomes terminating upstream of a splice site marked by ...
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD027487 | Pride
Nmd Smg1i Gigyf2. eif4e2 
ProteomicsDeciphering the role of the SMG1:SMG8:SMG9 complex during the first authentication step in NMD
Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA turnover pathway, which degrades transcripts containing premature termination codons. The execution of NMD requires the phosphorylation of N- and C-terminal tails of the key NMD factor UPF1, which thereby serve as binding platforms f...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD051058 | Pride
Smg8 Smg9 Smg1i Nmd Nonsense-mediated mrna decay Upf1 Smg1 
GenomicsIsoform characterization of m6A in single cells identifies its role in RNA surveillance [Direct RNA-seq for SMG1i treated]
Isoform characterization of m6A in single cells identifies its role in RNA surveillance [Direct RNA-seq for SMG1i treated]
PRJNA1069632 | ENA
TranscriptomicsRNA-Seq of SMG1-SMG8-SMG9 complex alterations in human osteosarcoma cell line U2OS
Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA turnover pathway, which degrades transcripts containing premature termination codons. The execution of NMD requires the phosphorylation of N- and C-terminal tails of the key NMD factor UPF1, which thereby serve as binding platforms f...
ORGANISM(S): Homo sapiens 
2026-02-13 | E-MTAB-16399 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of SMG1-SMG8-SMG9 complex alterations in human colorectal adenocarcinoma cell line HCT116
Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA turnover pathway, which degrades transcripts containing premature termination codons. The execution of NMD requires the phosphorylation of N- and C-terminal tails of the key NMD factor UPF1, which thereby serve as binding platforms f...
ORGANISM(S): Homo sapiens 
2026-02-13 | E-MTAB-13949 | biostudies-arrayexpress
TranscriptomicsU2AF1 Mutant Myeloid Neoplasms are Preferentially Sensitive to In Vivo Inhibition of Nonsense-Mediated RNA Decay
Expression of mutant spliceosome proteins (e.g., U2AF1S34F, SF3B1K700E, or SRSF2P95H) alters RNA splicing in myeloid neoplasms, leading to increased production of nonsense transcripts. We have previously shown that inhibiting the nonsense–mediated RNA decay (NMD) pathway, which is responsible for de...
ORGANISM(S): Homo sapiens Mus musculus 
2026-02-09 | GSE298283 | GEO
UnknownComprehensive Analysis of Combinatorial Pharmacological Treatments to Correct Nonsense Mutations in the CFTR Gene.
Not available
S-EPMC8584557 | biostudies-literature
UnknownA system of reporters for comparative investigation of EJC-independent and EJC-enhanced nonsense-mediated mRNA decay.
Not available
S-EPMC10680754 | biostudies-literature
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