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ProteomicsDeciphering the role of the SMG1:SMG8:SMG9 complex during the first authentication step in NMD
Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA turnover pathway, which degrades transcripts containing premature termination codons. The execution of NMD requires the phosphorylation of N- and C-terminal tails of the key NMD factor UPF1, which thereby serve as binding platforms f...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD051058 | Pride
Smg8 Smg9 Smg1i Nmd Nonsense-mediated mrna decay Upf1 Smg1 
ProteomicsQuantitative proteomic dataset of the moss Physcomitrium patens SMG1 KO mutant line
Here, we provide an isobaric tag for relative and absolute quantitation (iTRAQ)-based quantitative proteomic dataset of the moss Physcomitrium patens smg1 knockout line. The kinase SMG1 is one of the key components of the NMD system in many organisms, including plants. Several lines with a deleted...
ORGANISM(S): Physcomitrella patens subsp. patens (Moss) 
2021-11-02 | PXD029205 | Pride
Nmd Physcomitrium patens Itraq 
TranscriptomicsRNA-Seq of SMG1-SMG8-SMG9 complex alterations in human colorectal adenocarcinoma cell line HCT116
Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA turnover pathway, which degrades transcripts containing premature termination codons. The execution of NMD requires the phosphorylation of N- and C-terminal tails of the key NMD factor UPF1, which thereby serve as binding platforms f...
ORGANISM(S): Homo sapiens 
2026-02-13 | E-MTAB-13949 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of SMG1 inhibition via SMG1i in human foreskin fibroblast (HFF) and human umbilical vein endothelial cells (HUVEC)
UPF1 is a multi-domain RNA helicase that constantly monitors the transcriptome by non-specifically binding to mRNAs, dissociating from non-target transcripts, and initiating degradation on selected target RNAs via multiple proposed pathways such as nonsense-mediated decay (NMD). NMD is a translation...
ORGANISM(S): Homo sapiens 
2025-09-01 | E-MTAB-14755 | biostudies-arrayexpress
UnknownSmg1 haploinsufficiency predisposes to tumor formation and inflammation.
Not available
S-EPMC3557096 | biostudies-literature
UnknownCryo-EM structure of SMG1-SMG8-SMG9 complex.
Not available
S-EPMC6951342 | biostudies-literature
GenomicsRNA-Seq of SMG1-SMG8-SMG9 complex alterations in human osteosarcoma cell line U2OS
RNA-Seq of SMG1-SMG8-SMG9 complex alterations in human osteosarcoma cell line U2OS
PRJEB105553 | ENA
GenomicsRNA-Seq of SMG1-SMG8-SMG9 complex alterations in human colorectal adenocarcinoma cell line HCT116
RNA-Seq of SMG1-SMG8-SMG9 complex alterations in human colorectal adenocarcinoma cell line HCT116
PRJEB74777 | ENA
UnknownSMG1 and NIK regulate apoptosis induced by Smac mimetic compounds.
Not available
S-EPMC3122057 | biostudies-literature
UnknownThe RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.
Not available
S-EPMC4743010 | biostudies-literature
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