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TranscriptomicsTranscriptional profiling of Th1, Th2, Th9, and Th17 T cell clones
We next sought to identify the transcriptional program that differentiates IL-9+Th2 cells from “conventional” Th2 cells. To this end, we selected representative Th1, Th17, Th2, and IL-9+Th2 clones (Figure 5A) and determined their transcriptome in the resting state and at different time points after ...
ORGANISM(S): Homo sapiens 
2017-11-10 | E-MTAB-5739 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human Th9 T cell clones treated with GW9662 against untreated control
To investigate the role of PPAR-γ in human TH cells, transcriptional response of activated “TH9” clones to treatment with GW9662, a potent PPAR-γ antagonist was assessed. “TH9” cell clones were incubated with GW9662 for 48h and activated with αCD3/2/28 for 12 h. Transcriptomic profiling was performe...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12197 | biostudies-arrayexpress
TranscriptomicsProgesterone-regulated genes in immune cells: Regulation of T cell genes by progesterone
We examined the global gene expression pattern of T cells regulated by progesterone to gain further insights into the regulatory mechanisms of progesterone. We found 325-347 cord blood T cell genes up or down-regulated by P4 in the presence or absence of exogenous TGFb1. Peripheral blood T cells wer...
ORGANISM(S): Homo sapiens 
2012-03-02 | E-GEOD-22025 | biostudies-arrayexpress
TranscriptomicsDigoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity
CD4+ T helper lymphocytes that express interleukin-17 (Th17 cells) have critical roles in mouse models of autoimmunity, and there is mounting evidence that they also influence inflammatory processes in humans. Genome-wide association studies in humans have linked genes involved in Th17 cell differe...
ORGANISM(S): Mus musculus 
2011-03-28 | E-GEOD-27241 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human in vitro primed Th9 T cells (day 20) treated with GW9662 against untreated control
To investigate the role of PPAR-γ in human TH cells, transcriptional response in vitro primed Th9 cells to treatment with GW9662, a potent PPAR-γ antagonist was assessed. In vitro primed Th9 cells (day 20) were incubated with GW9662 for 48h. Transcriptomic profiling was performed by bulk RNA-seq. To...
ORGANISM(S): Homo sapiens 
2024-11-29 | E-MTAB-14444 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human in vitro primed Th1, Th2, Th9 and Treg T cells
To test whether human in vitro primed Th9 cells recapitulate the core pathogenic Th2 cell phenotype, we differentiated naïve T cells into Th1 (IL-12), Th2 (IL-4), Th9 (IL-4+TGF-β), and iTreg (TGF-β). After 7 days transcriptomic profiling by bulk RNA-seq was performed.
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12199 | biostudies-arrayexpress
TranscriptomicsDefining a Th9 transcriptome
Microarray analyses were performed to compare gene expression in cultured mouse Th9, Th2 and Treg cells and resting versus activated Th9 cells. Three replicates were analyzed for each culture condition; Th9 unstim, Th2 unstim, Treg unstim, Th9 stim
ORGANISM(S): Mus musculus 
2014-03-26 | E-GEOD-44937 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human IL-9R+ T helper cells in presence of recombinant IL-9 against untreated control
To study the effect of paracrine interleukin-9 (IL-9) on T helper cells, we incubated IL-9R+ T helper cells isolated from blood (5 samples) and skin (3 samples) with or without IL-9 for 12h and the transcriptome was analyzed by bulk RNA-seq.
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12204 | biostudies-arrayexpress
UnknownT(H)1, T(H)2, and T(H)17 cells instruct monocytes to differentiate into specialized dendritic cell subsets.
Not available
S-EPMC3179399 | biostudies-literature
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Wild Type, DDX5 knockout, RORc knockout, RmrpG262T knockin T helper 17 cell Transcriptomes [RNA-seq]
Purpose: The goals of this study are to compare in vitro polarized T helper 17 cell transcriptome profiling (RNA-seq) in different genetic background. Methods: Th17 mRNA profiles of 96hrs in vitro cultured T helper 17 cells from wild-type and mutant mice were generated by deep sequencing, using Ill...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-70108 | biostudies-arrayexpress
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