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UnknownEffect of Obesity and High-Density Lipoprotein Concentration on the Pathological Characteristics of Alzheimer's Disease in High-Fat Diet-Fed Mice.
The typical pathological features of Alzheimer's disease (AD) are the accumulation of amyloid plaques in the brain and reactivity of glial cells such as astrocytes and microglia. Clinically, the development of AD and obesity are known to be correlated. In this study, we analyzed the changes in AD pa...
S-EPMC9603479 | biostudies-literature
UnknownSex-specific association between body mass index and cerebral microbleed progression in adults aged 50-85 years.

Background and purpose

Previous studies have demonstrated sex differences in the association between body mass index (BMI) and hemorrhagic stroke. Cerebral microbleed (CMB) is a clinically important marker of bleeding-prone microangiopathy, which is associated with a risk of hemorrhagic stro...
S-EPMC12450651 | biostudies-literature
UnknownAngiotensin-converting enzyme insertion/deletion gene polymorphism and the progression of cerebral microbleeds.

Background and purpose

The angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism has been studied as a genetic candidate for cerebral small vessel disease (CSVD). However, no previous study has evaluated the relationship between the ACE I/D polymorphism and cerebral mic...
S-EPMC10602736 | biostudies-literature
UnknownDHA Induces Cell Death through the Production of ROS and the Upregulation of CHOP in Fibroblast-like Synovial Cells from Human Rheumatoid Arthritis Patients.
Rheumatoid arthritis (RA) is an inflammatory disease marked by a massive proliferation of synovial cells in the joints. In this study, we investigated the pro-apoptotic effects of docosahexaenoic acid (DHA) in human fibroblast-like synovial cells from RA patients (RA-FLS). An in vitro study using MH...
S-EPMC9865349 | biostudies-literature
UnknownTransferrin-Conjugated Melittin-Loaded L-Arginine-Coated Iron Oxide Nanoparticles for Mitigating Beta-Amyloid Pathology of the 5XFAD Mouse Brain.
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases and a major contributor to dementia. Although the cause of this condition has been identified long ago as aberrant aggregations of amyloid and tau proteins, effective therapies for it remain elusive. The complexities of...
S-EPMC10573775 | biostudies-literature
UnknownEffect Sizes of Cognitive and Locomotive Behavior Tests in the 5XFAD-J Mouse Model of Alzheimer's Disease.
Alzheimer's disease (AD) is characterized by the accumulation of amyloid β (Aβ) plaques in the brain, leading to cognitive impairment and other clinical symptoms. The 5XFAD mouse model is commonly used in AD research because it expresses five human transgenes that result in the accumulation of Aβ pl...
S-EPMC10606448 | biostudies-literature
UnknownDe-escalation from ticagrelor to clopidogrel in patients with acute myocardial infarction: the TALOS-AMI HBR substudy.

Background

The benefits of de-escalation of P2Y12 inhibition after percutaneous coronary intervention (PCI) may differ by high bleeding risk (HBR) status.

Aims

We investigated the efficacy and safety of de-escalation from ticagrelor to clopidogrel after PCI by HBR status.
S-EPMC10687647 | biostudies-literature
UnknownHybrid Electro-optical Stimulation Improves Ischemic Brain Damage by Augmenting the Glymphatic System.
Ischemic brain injury not only results in significant neurological, motor, and cognitive impairment but also contributes to the accumulation of toxic solutes and proinflammatory cytokines in the infarction region, exacerbating ischemic brain damage. The glymphatic system, which is crucial for brain ...
S-EPMC11967803 | biostudies-literature
UnknownIdentification of stroke biomarkers using proteomic profiling of extracellular vesicles derived from human blood: a preliminary study.

Introduction

Stroke is a devastating brain disease that causes extensive neurological impairment and high mortality. Rapid diagnosis and intervention of stroke are necessary to minimize neurological damage and improve recovery. Extracellular vesicles (EVs) have been identified as potential b...
S-EPMC12265495 | biostudies-literature
UnknownEEG-based detection of early functional brain changes in subjective cognitive decline: a prospective cohort study.

Background

Subjective cognitive decline (SCD) has been recognized as a preclinical stage of Alzheimer's disease. However, the identification of early functional brain changes remains challenging. This study investigated the functional brain changes in SCD using longitudinal EEG and evaluate ...
S-EPMC12751729 | biostudies-literature
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