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TranscriptomicsRe-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis
Biogenesis of canonical microRNAs (miRNAs) involves multiple steps: nuclear processing of primary miRNA (pri-miRNA) by DROSHA, nuclear export of precursor miRNA (pre-miRNA) by Exportin 5 (XPO5), and cytoplasmic processing of pre-miRNA by DICER. To gain a deeper understanding of the contribution of e...
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-77989 | biostudies-arrayexpress
UnknownIntegrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.

Purpose

Lung squamous cell carcinoma (SCC) is the second most prevalent type of lung cancer. Currently, no targeted therapeutics are approved for treatment of this cancer, largely because of a lack of systematic understanding of the molecular pathogenesis of the disease. To identify therapeu...
S-EPMC4062710 | biostudies-literature
TranscriptomicsAgo2 or Dicer knockdown effects on mRNA levels in HeLa
Analysis of mRNA changes in HeLa cells following Ago2 or Dicer depletion. Dicer, a cytoplasmic RNase III, generates the mature form of small RNAs including microRNA. Ago2 is a component of an effector complex of microRNA. Keywords: gene expression array-based (RNA / in situ oligonucleotide) siRNA a...
ORGANISM(S): Homo sapiens 
2009-02-04 | E-GEOD-13638 | biostudies-arrayexpress
UnknownRare X-linked variants carry predominantly male risk in autism, Tourette syndrome, and ADHD.
Autism spectrum disorder (ASD), Tourette syndrome (TS), and attention-deficit/hyperactivity disorder (ADHD) display strong male sex bias, due to a combination of genetic and biological factors, as well as selective ascertainment. While the hemizygous nature of chromosome X (Chr X) in males has long ...
S-EPMC10700338 | biostudies-literature
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