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TranscriptomicsTranscription profiling of human U927 cells polysomal and cytoplasmic RNA before and after PMA stimulation
Human histomonocytic U937 cells exhibit macrophage-like properties after phorbol ester stimulation. Accumulating evidence demonstrated that remarkable number of transcripts changed in their amount at total RNA levels. However, post-transcriptional regulation has not been fully elucidated in this m...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1783 | biostudies-arrayexpress
GenomicsExpanding the CTD code: methylation of non-consensus Lysine residues marks early transcription in mammalian cells
Dynamic post-translational modification of RNA polymerase II (RNAPII) coordinates the co-transcriptional recruitment of enzymatic complexes that regulate chromatin states and co-transcriptional processing of nascent RNA. Extensive phosphorylation of serine residues occurs at the structurally-disorde...
ORGANISM(S): Mus musculus 
2015-12-22 | E-GEOD-72876 | biostudies-arrayexpress
TranscriptomicsHistone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.
In budding yeast, Set2 catalyzes di- and trimethylation of H3K36 (H3K36me2 and H3K36me3) via an interaction between its SRI domain and C-terminal repeats of RNA polymerase II (Pol2) phosphorylated at Ser2 and Ser5 (CTD-S2,5-P). H3K36me2 recruits the Rpd3S histone deacetylase complex to repress crypt...
ORGANISM(S): Schizosaccharomyces pombe 
2016-02-04 | E-GEOD-66821 | biostudies-arrayexpress
TranscriptomicsNOTCH3 knockdown in non-transformed human esophageal cells
To determine the role of NOTCH3 in human esophageal epitheila homeostasis/squamous cell differentiation Zinc finger E-box binding (ZEB) proteins ZEB1 and ZEB2 are transcription factors essential in transforming growth factor (TGF)-β-mediated epithelial to mesenchymal transition (EMT), senescence an...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-27424 | biostudies-arrayexpress
UnknownVisualizing histone modifications in living cells: spatiotemporal dynamics of H3 phosphorylation during interphase
Not available
S-JCBD-200904137 | bioimages
ProteomicsPlasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice
This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in spaceflight-induced deterioration of muscul...
ORGANISM(S): Mus Musculus (mouse) 
2024-02-01 | PXD041806 | JPOST Repository
TranscriptomicsMammalian NET-seq reveals genome-wide nascent transcription coupled to RNA processing
We have generated single-nucleotide resolution, nascent transcription profiles from HeLa cells by developing Native Elongation Transcript sequencing technology for mammalian chromatin (mNET-seq). Our extensive data sets provide a substantial resource to study mammalian nascent transcript profiles. W...
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-60358 | biostudies-arrayexpress
ProteomicsPancreatic cancer proteome from paraffin-embedded tissue
Formalin fixed paraffin-embedded pancreas tissues were deparaffinized by two changes of xylene and washed with descending concentrations of ethanol. Proteins in the deparaffinized tissues were extracted in 20%(w/v) of 200 mM Tris-HCl (pH 8.8) containing 2% SDS and 0.2 M DTT followed by incubation at...
ORGANISM(S): Homo Sapiens (human) 
2021-10-27 | PXD025975 | JPOST Repository
ProteomicsMS analysis of phosphopeptides enriched from the lumbar spinal cord of SOD1G93A mice at 20weeks.
This project is "Phosphoproteomic analysis of the lumbar spinal cord, a lesion site in the amyotrophic lateral sclerosis (ALS) mouse model SOD1G93A mice". The aim of this study is to clarify the phosphorylation changes by the lumbar spinal cord of SOD1G93A mice at 20w by applying proteomics technolo...
ORGANISM(S): Mus Musculus (mouse) 
2022-05-19 | PXD030651 | JPOST Repository
ProteomicsSerum proteome profiling of patients with non-small cell lung cancer treated with immune checkpoint blockade monotherapy
Shotgun proteomic profiling of serum from patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint blockade (ICB) monotherapy. Top-14 abundant proteins were depleted (Pierce High-Select, Thermo Fisher Scientific), and tryptic digests were spiked with the Pierce Peptide Retenti...
ORGANISM(S): Homo Sapiens (human) 
2026-06-10 | PXD078247 | JPOST Repository
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