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TranscriptomicsTranscription profiling of human neuroblastoma cell line IMR-32 overexpressiong SQSTM1 and DPP3 to identify activators for the antioxidant response element
The antioxidant response element (ARE) is a cis-acting regulatory enhancer element found in the 5’ flanking region of many phase II detoxification enzymes. Upregulation of ARE-dependent target genes is known to have neuroprotective effects; yet, the mechanism of activation is largely unknown. By scr...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-6451 | biostudies-arrayexpress
ProteomicsDEAD box RNA helicases are pervasive protein kinase interactors and activators
DEAD box (DDX) RNA helicases are a large family of ATPases, many of which have unknown functions. There is emerging evidence that besides their role in RNA biology, DDX proteins may stimulate protein kinases. To investigate if protein kinase-DDX interaction is a more widespread phenomenon, we conduc...
ORGANISM(S): Homo sapiens (Human) 
2024-03-10 | PXD043289 | Pride
Kinase activators Rna helicases Interactome 
UnknownPyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Not available
S-EPMC3711671 | biostudies-literature
UnknownDevelopment of Brain Penetrant Pyridazine Pantothenate Kinase Activators.
Not available
S-EPMC11345825 | biostudies-literature
TranscriptomicsTranscription profiling of adult mouse heart following activation of Ras, MKK3 and MKK7 mutant genes
Three major MAP kinase signaling cascades, ERK, p38 and JNK, play significant roles in the development of cardiac hypertrophy and heart failure in response to external stress and neural/hormonal stimuli. In order to study the specific function of each MAP kinase branch in adult heart, we have gener...
ORGANISM(S): Mus musculus 
2007-10-12 | E-GEOD-3530 | biostudies-arrayexpress
UnknownPyruvate kinase activators: targeting red cell metabolism in thalassemia.
Not available
S-EPMC10727068 | biostudies-literature
UnknownPyruvate kinase activators: targeting red cell metabolism in sickle cell disease.
Not available
S-EPMC10727103 | biostudies-literature
UnknownActivators and Inhibitors of Protein Kinase C (PKC): Their Applications in Clinical Trials.
Not available
S-EPMC8621927 | biostudies-literature
UnknownRegulation of AMP-activated protein kinase by natural and synthetic activators.
Not available
S-EPMC4724661 | biostudies-literature
UnknownNucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma.
Not available
S-EPMC6440977 | biostudies-literature
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