Sort   by:  
 Page size 
ProteomicsAutoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility
Genetic association links DIORA1 to numerous autoimmune rheumatic diseases including systemic lupus erythematous, Sjögren's disease, myositis, scleroderma and rheumatoid arthritis, but its cellular function remains unknown. Here, we identify the MRCK kinase family as DIORA1 interactors. MRCK kinases...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD064939 | Pride
Autoimmunity Epithelial-mesenchymal transition (emt) Rho gtpase signaling Diora1 Mrck kinases Kinase inhibitory motif (kim) Cancer Cell motility Cytoskeleton Fam167a 
UnknownPEBP1, a RAF kinase inhibitory protein, negatively regulates starvation-induced autophagy by direct interaction with LC3.
Not available
S-EPMC5103343 | biostudies-literature
UnknownEnhancing and inhibitory motifs regulate CD4 activity.
Not available
S-EPMC9333989 | biostudies-literature
TranscriptomicsAutoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility
Genetic association links DIORA1 to numerous autoimmune rheumatic diseases, including systemic lupus erythematosus, Sjögren's disease, rheumatoid arthritis, polymyositis and systemic sclerosis. However, its cellular function has remained unknown. Here, we identify the MRCK family of serine/threonine...
ORGANISM(S): Homo sapiens 
2025-09-08 | GSE299540 | GEO
TranscriptomicsAn PWI- and RRM Motif-Containing Protein Is Critical for Pre-mRNA Splicing and ABA Responses in Arabidopsis
We used RNA-seq platform to determine role of a splicing factor RBM25 in regulation of gene expression and pre-mRNA splicing. We found that a loss-of-function allele of RBM25, rbm25-1, causes up- and down-regulation of a large number of genes. We further found that the rbm25-1 mutation results in d...
ORGANISM(S): Arabidopsis thaliana 
2015-10-28 | E-GEOD-66737 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse iPS cells from neural stem cells by 2 factors (Oct4, KLF4) (Kim, Zaehres et al.)
Reprogramming of somatic cells is a valuable tool to understand the mechanisms of regaining pluripotency and further opens up the possibility to generate patient-specific pluripotent stem cells. Reprogramming of mouse and human somatic cells into pluripotent stem cells, designated as induced pluripo...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-10806 | biostudies-arrayexpress
TranscriptomicsDifferences in CTCF binding site sequence are associated with unique regulatory and functional trends during embryonic stem cell differentiation [RNA-Seq]
CTCF (CCCTC-binding factor) is a highly conserved 11-zinc finger DNA binding protein with tens of thousands of binding sites genome-wide. CTCF acts as a multifunctional regulator of transcription, having been previously associated with activator, repressor, and insulator activity. These diverse regu...
ORGANISM(S): Mus musculus 
2013-10-11 | E-GEOD-39522 | biostudies-arrayexpress
UnknownHA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice.
Not available
S-EPMC6102265 | biostudies-literature
TranscriptomicsLIN28A-mediated regulation of microRNA biogenesis in mouse embryonic stem cell (A3-1) [Agilent]
LIN28A is a highly-conserved RNA-binding protein which is known to be involved in embryonic development, stem cell maintenance and proliferation. LIN28A is expressed in various types of cancer, and they are associated with advanced tumor malignancy. In embryonic stem cell, LIN28A specifically binds ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-37112 | biostudies-arrayexpress
TranscriptomicsExpression data from embryonic stem cells (ESCs) and ESC-like cells
The transplantation of ESCs into living recipients causes teratoma formation which accompanies with several biological reactions in both the transplanted cells and recipient. Co-injection of ESCs with somatic cells that influence donor-recipient homogeneity can affect transcriptional profile of tran...
ORGANISM(S): Mus musculus 
2014-06-23 | E-GEOD-58725 | biostudies-arrayexpress
Sort   by:  
 Page size