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GenomicsHistone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells [ChIP-Seq]
Variation in chromatin composition and organization often reflects differences in genome function. Histone variants, for example, replace canonical histones to contribute to regulation of numerous nuclear processes including transcription, DNA repair and chromosome segregation. Here we focus on H2A....
ORGANISM(S): Homo sapiens 
2012-07-16 | E-GEOD-38284 | biostudies-arrayexpress
TranscriptomicsA Region of Human HoxD that Confers Polycomb-Group Responsiveness
Polycomb group (PcG) proteins are essential for accurate axial body patterning during embryonic development. PcG-mediated repression is conserved in metazoans and is targeted in Drosophila by Polycomb response elements (PREs). Targeting sequences in humans have not been described. While analyzing c...
ORGANISM(S): Homo sapiens 
2010-06-19 | E-GEOD-19046 | biostudies-arrayexpress
GenomicsH3K27 modifications define segmental regulatory domains in the Drosophila bithorax complex.
The bithorax complex (BX-C) in the fruit fly, Drosophila melanogaster, is a cluster of homeotic genes that determines the identities the body segments. Expression of these genes is governed by cis-regulatory domains, one for each parasegment, which are arranged on the chromosome in the order of the...
ORGANISM(S): Drosophila melanogaster 
2014-08-14 | E-GEOD-55257 | biostudies-arrayexpress
GenomicsThe Genomic Binding Sites of an Endogenous Non-Coding RNA
Long non-coding RNAs (lncRNAs) have important regulatory roles and can function at the level of chromatin. To determine where lncRNAs bind to chromatin, we developed CHART, a hybridization-based technique that specifically enriches endogenous RNAs along with their targets from reversibly-crosslinked...
ORGANISM(S): Drosophila melanogaster 
2011-12-07 | E-GEOD-28180 | biostudies-arrayexpress
TranscriptomicsHigh-resolution chromosomal maps of Xist RNA reveal a two-step spreading mechanism during X-inactivation
The Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation (XCI), the process by which mammals compensate for unequal numbers of sex chromosomes. During XCI, Xist coats the future inactive X (Xi) and recruits Polycomb Repressive Complex 2 (PRC2) to the X-inactivation center (Xic...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-48649 | biostudies-arrayexpress
UnknownHaploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism spectrum disorder.
Not available
S-EPMC8206166 | biostudies-literature
UnknownCharacterizing Long COVID in Children and Adolescents.
Not available
S-EPMC11339705 | biostudies-literature
UnknownCHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.
Not available
S-EPMC6218476 | biostudies-literature
UnknownBrain charts for the human lifespan.
Not available
S-EPMC9021021 | biostudies-literature
UnknownHeterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight.
Not available
S-EPMC7943191 | biostudies-literature
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