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TranscriptomicsTranscription profiling of human dermal pericytes compared to the remaining dermal cells of neonatal human foreskin
Pericytes derived from skin dermis can substantially enhance the short-term tissue-regenerative capacity of human epidermal cells already committed to differentiation; they also display both phenotypic and functional properties of mesenchymal stem cells. In this microarray analysis, we compared the ...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-17014 | biostudies-arrayexpress
TranscriptomicsGene signatures in prostate cancer linked to the Gleason score
The identification of novel oncogenic and druggable targets in patient subgroups with poor prognosis may help to develop corresponding targeted therapy approaches. Microarray data analyses of 59 prostate cancer and 39 benign tissue samples revealed major transcriptional differences. More than 5.000 ...
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-32571 | biostudies-arrayexpress
TranscriptomicsSiomycin A treatment in prostate cancer cell lines PC3 and LNCaP
Siomycin A treatment in prostate cancer cell lines resulted in a concurrent inhibition of specific cell cycle genes and strongly impaired cell viability. Illumina microarray experiments were done using PC3 and LNCaP cell lines treated with 0.5 microM Siomaycin A either 24h or 48h in triplicates.
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-36531 | biostudies-arrayexpress
TranscriptomicsDissecting the Genetics of the Human Transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci
Genetics of gene expression (eQTLs or expression QTLs) has proved an indispensable tool for understanding biological pathways and pathomechanisms of trait associated SNPs. However, power of most genome-wide eQTL studies is still limited. We performed a large eQTL study in peripheral blood mononuclea...
ORGANISM(S): Homo sapiens 
2015-06-29 | E-GEOD-65907 | biostudies-arrayexpress
TranscriptomicsReconstruction of gene interaction networks by in vitro RNA interference and global expression analysis
We here used the technology of RNA interference or selective treatment of the ESR1 and cDNA microarrays to reconstruct a network between genes known to be disregulated in ER-positive breast cancer diseases. Therefor single genes of high importance were silenced and the effect of this pertubation was...
ORGANISM(S): Homo sapiens 
2009-07-29 | E-GEOD-12291 | biostudies-arrayexpress
TranscriptomicsMELK and UBE2C gene knockdown in prostate cancer cell line PC3
In order to address the putative role of MELK and UBE2C in prostate cancer development and progression, we performed functional analysis upon siRNA-based knockdown, and searched for downstream genes and processes by microarray experiments. RNAi-based inhibition of MELK and UBE2C was efficient in PC3...
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-32873 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis mutants (elo2, elo3, drl1-2 and ang4) vs the wild type Ler strain
Microarray transcript profiling and RNA interference are two new technologies crucial for large-scale gene function studies in multicellular eukaryotes. Both rely on sequence-specific hybridization between complementary nucleic acid strands, inciting us to create a collection of gene-specific sequen...
ORGANISM(S): Arabidopsis thaliana 
2004-05-07 | E-MEXP-30 | biostudies-arrayexpress
TranscriptomicsPropionibacterium acnes as a frequent inflammatory agent involved in prostate cancer
Prostate cancer is the second leading cause of male cancer deaths in the United States and Europe. Current evidence implicates an inflammatory mechanism as a cause of prostate carcinogenesis. Here we show that the bacterium Propionibacterium acnes (P. acnes) is prevalent in prostate glandular tissue...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-18109 | biostudies-arrayexpress
TranscriptomicsIdentification of Novel Cholesteatoma-related Gene Expression Signatures Using Full-genome Microarrays
In this study, we investigated differentially expressed genes in human cholesteatomas in comparison to regular auditory canal skin using Whole Human Genome Microarrays that contain 19,596 human genes. In addition to already described up-regulated mRNAs in cholesteatoma, such as MMP9, DEFB2 and KRT1...
ORGANISM(S): Homo sapiens 
2012-11-14 | E-GEOD-42256 | biostudies-arrayexpress
TranscriptomicsUGE and UGM Reveal Novel Signaling Pathways and Ligand-Receptor Interactions in the Primitive Prostate Stem Cell Niche
We isolated fetal murine urogenital sinus epithelium and urogenital sinus mesenchyme and determined their global gene expression profiles to define their differentially expressed regulators. To distinguish gene expression patterns that are shared by other developing epithelial/mesenchymal compartmen...
ORGANISM(S): Mus musculus 
2010-08-29 | E-GEOD-17797 | biostudies-arrayexpress
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