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ProteomicsProteome of senescent human lung fibroblasts and Panc-1 cells
Proteomic analysis of proliferating and senescent normal healthy lung fibroblasts (NHLFs) and Panc-1 cells. Senescence was induced using 5 uM Palbociclib for 6 days. Cells were lysed in SDS lysis buffer (2% SDS in 100 mM TEAB), boiled (15 min, 95 °C, 500 rpm) and sonicated in a sonication bath (10 ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-28 | MSV000090607 | MassIVE
TranscriptomicsExpression profile of Maize (Zea mays L.) Embryonic Axes During Germination: Regulation of Ribosomal Protein mRNAs.
Seed germination is a critical developmental process in plant propagation. Knowledge of the gene expression patterns in this critical process is important in order to understand the main biochemical reactions involved in successful germination, specially for economically relevant plants such as M...
ORGANISM(S): Zea mays 
2011-07-31 | E-GEOD-27648 | biostudies-arrayexpress
TranscriptomicsComparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas
The goal of the present study was to characterize HLA-G-positive cells derived from human embryonic stem cells treated with BMP4 for five days and compare them to HLA-G positive cells derived from human first trimester placentas Human embryonic stem cells were cultured with BMP4 in the absence of F...
ORGANISM(S): Homo sapiens 
2013-05-02 | E-GEOD-42112 | biostudies-arrayexpress
TranscriptomicsGene expression profile from field-grown drought-stressed cotton
Drought-responsive genes were identified in leaf tissues of the cotton Acala 15-1799, a cotton genotype derived in the Southwest USA. Most of the identified genes such as the heat shock proteins have been described as responsive to drought and heat in other plant species. Microarray analysis was us...
ORGANISM(S): Gossypium hirsutum 
2010-05-22 | E-GEOD-18253 | biostudies-arrayexpress
GenomicsGlobal genomic profiling of p53-regulated genes
p53 is a critical tumor suppressor and works as a stress-induced transcription factor to induce target genes mediating apoptosis, cell cycle arrest and senescence or other responses. To gain new insights into p53 biology, we used high-throughput sequencing to analyze global p53 transcriptional netwo...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46240 | biostudies-arrayexpress
TranscriptomicsExpression data from CD71+ cells from the bone marrow of WT, CD70TG, IFNg-/- and CD70TG*IFNg-/- mice.
CD70TG mice are a model for sterile chronic immune activation and develop Anemia of Inflammation, which is dependent on the production of Ifng by effector CD4 and CD8 T cells. We used microarrays to identify Ifng-dependent differentially expressed genes that could account for the erythropoietic defe...
ORGANISM(S): Mus musculus 
2011-07-31 | E-GEOD-22656 | biostudies-arrayexpress
TranscriptomicsDiscovery cohort for genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
PURPOSE: To develop a predictive test for response and survival following neoadjuvant taxane-anthracycline chemotherapy for HER2-negative invasive breast cancer. METHODS: We developed a microarray-based gene expression test from pre-treatment tumor biopsies (310 patients) to predict favorable outcom...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-25055 | biostudies-arrayexpress
TranscriptomicsRegional centromeres in Candida lusitaniae lack pericentromeric heterochromatin (RNA-seq)
We sequenced mRNA from wild type and Hst1 knock out strains of Candida lusitaniae to generate the gene expression profiles and studied the differentially expressed genes between the two conditions. RNA profiles of wild type (WT) and Hst1 knockout of Candida lusitaniae were generated by deep sequenci...
ORGANISM(S): Clavispora lusitaniae 
2015-09-14 | E-GEOD-71658 | biostudies-arrayexpress
TranscriptomicsPRONOUNCED PHENOTYPE IN ACTIVATED TREG CELLS DURING A CHRONIC HELMINTH INFECTION
Although several markers have been associated with the characterization of regulatory T cells (Treg) and their function, no studies have investigated the dynamics of their phenotype during infection. Since the necessity of Treg to control immunopathology has been demonstrated, we used the chronic he...
ORGANISM(S): Mus musculus 
2010-04-12 | E-GEOD-17580 | biostudies-arrayexpress
TranscriptomicsSIRT1 affects DNA methylation of polycomb group protein target genes (PCGTs), a hotspot of the epigenetic shift observed in ageing
Beneficial effects of SIRT1 on healthspan are likely to be pleiotropic and may include effects on DNA methylation. We demonstrated recently that manipulating SIRT1 in human cells affected DNA methylation of a panel of test genes, and that genes with expression modified by dietary restriction corresp...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-53569 | biostudies-arrayexpress
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